Metathesis in natural product synthesis [[electronic resource] ] : strategies, substrates and catalysts / / edited by Janine Cossy, Stellios Arseniyadis, and Christophe Meyer ; with a foreword by Robert H. Grubbs

• Record Nr.: UNINA9910830522703321
• Pubbl/distr/stampa: Weinheim, : Wiley-VCH, c2010
• ISBN: 3-527-64208-0; 1-283-51405-2; 9786613826503; 3-527-62963-7; 3-527-62962-9
• Descrizione fisica: 1 online resource (414 p.)
• Altri autori (Persone): CossyJanine; ArseniyadisS (Stellios); MeyerChristophe
• Disciplina: 547.2
• Soggetti: Natural products - Synthesis; Metathesis (Chemistry)
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts; Contents; Foreword; Preface; List of Catalysts; List of Contributors; Abbreviations; 1 Synthesis of Natural Products Containing Medium-size Carbocycles by Ring-closing Alkene Metathesis; 1.1 Introduction; 1.2 Formation of Five-membered Carbocycles by RCM; 1.3 Formation of Six-membered Carbocycles by RCM; 1.4 Formation of Seven-membered Carbocycles by RCM; 1.5 Formation of Eight-membered Carbocycles by RCM; 1.6 Formation of Nine-membered Carbocycles by RCM; 1.7 Formation of 10-membered Carbocycles by RCM; 1.8 ConclusionReferences; 2 Natural Products Containing Medium-sized Nitrogen Heterocycles Synthesized by Ring-closing Alkene Metathesis; 2.1 Introduction; 2.2 Five-membered Nitrogen Heterocycles; 2.2.1 Dihydropyrroles; 2.2.2 Pyrrolidine Alkaloids; 2.2.2.1 ; Pyrrolidines; 2.2.2.2 Dipyrrolidines; 2.2.2.3 Polyhydroxypyrrolidines; 2.2.3 Indolizidine Alkaloids; 2.2.3.1 Polycyclic Indolizidines; 2.2.3.2 Polyhydroxyindolizidines; 2.2.4 Pyrrolizidine Alkaloids; 2.3 Six-membered Nitrogen Heterocycles; 2.3.1 Piperidine Alkaloids; 2.3.1.1 Piperidines; 2.3.1.2 Piperidine Carboxylic Acids; 2.3.1.3 Piperidones2.3.1.4 Polyhydroxypiperidines; 2.3.2 Indolizidine Alkaloids; 2.3.3 Quinolizidine Alkaloids; 2.4 Seven-membered Nitrogen Heterocycles; 2.5 Eight-membered Nitrogen Heterocycles; 2.6 Conclusion; References; 3 Synthesis of Natural Products Containing Medium-size Oxygen Heterocycles by Ring-closing Alkene Metathesis; 3.1 Introduction; 3.2 General RCM Approaches to Medium Rings; 3.3 Laurencin; 3.4 Eunicellins/Eleutherobin; 3.5 Helianane; 3.6 Octalactin A; 3.7 Microcarpalide and the Herbarums; 3.8 Marine Ladder Toxins; 3.8.1 Ciguatoxin; 3.8.2 Brevetoxin; 3.8.3 Gambierol, Gambieric Acid, Olefinic-ester Cyclizations3.9 Conclusion; Acknowledgments; References; 4 Phosphorus and Sulfur Heterocycles via Ring-closing Metathesis: Application in Natural Product Synthesis; 4.1 Introduction; 4.2 Synthesis and Reactivity of Sultones Derived from RCM; 4.3 Total Synthesis of the Originally Proposed Structure of (±)-Mycothiazole; 4.4 Synthesis and Reactivity of Phosphates from RCM; 4.5 Applications of Phosphate Tethers in the Synthesis of Dolabelide C; 4.6 Conclusion; Acknowledgment; References; 5 Synthesis of Natural Products Containing Macrocycles by Alkene Ring-closing Metathesis5.1 Introduction; 5.2 Organization of the Chapter; 5.3 Macrocyclic Polyketides; 5.3.1 Resorcinylic Macrolides; 5.3.2 Salicylate Macrolides; 5.3.3 Other Antibiotic Macrolides; 5.3.4 Macrocyclic Musk; 5.3.5 Epothilones; 5.3.6 Amphidinolides; 5.3.7 Other Polyketides; 5.3.8 Natural Cyclophanes; 5.4 Terpenoids; 5.4.1 Diterpenoids; 5.4.2 Macrocyclic Lipids; 5.5 Macrocycles of Amino Acid Origin; 5.5.1 Macrolactams; 5.5.2 Cyclodepsipeptides; 5.5.3 Alkaloids; 5.6 Macrocyclic Glycolipids; 5.7 Conclusions and Outlook; References
• Sommario/riassunto: Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications.

African arguments : Africa and the war on drugs / / Neil Carrier and Gernot Klantschnig

• Record Nr.: UNINA9910808819703321
• Autore: Carrier Neil
• Pubbl/distr/stampa: London, : Zed Books, 2012
• ISBN: 1-350-21810-3; 1-84813-969-1; 1-283-64099-6; 1-84813-968-3
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (135 p.)
• Collana: African arguments
• Altri autori (Persone): KlantschnigGernot <1977->
• Disciplina: 363.45096
• Soggetti: Drugs of abuse - Africa - History; Africa Politics and government
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Africa's drug habit -- Drugs and development : a new threat or opportunity? -- Drug barons, traffickers and mules : Africa as entrepôt -- African states and drugs : complexity, neglect and repression.
• Sommario/riassunto: Nigerian drug lords in UK prisons, khat-chewing Somali pirates hijacking Western ships, crystal meth-smoking gangs controlling South Africa's streets, and narco-traffickers corrupting the state in Guinea-Bissau: these are some of the vivid images surrounding drugs in Africa which have alarmed policymakers, academics and the general public in recent years. In this revealing and original book, the authors weave these aspects into a provocative argument about Africa's role in the global trade and control of drugs. In doing so, they show how foreign-inspired policies have failed to help African drug users but have strengthened the role of corrupt and brutal law enforcement officers, who are tasked with halting the export of heroin and cocaine to European and American consumer markets. A vital book on an overlooked front of the so-called war on drugs.