Ciba Foundation Symposium jointly with Committee for Symposia on Drug Action, on Adrenergic Mechanisms [[electronic resource] /] / editor for the British Pharmacological Society, J.R. Vane ; editors for the Ciba Foundation, G.E.W. Wolstenholme and Maeve O'Connor

• Record Nr.: UNINA9910830509503321
• Pubbl/distr/stampa: Boston, : Little, Brown and Co., [1961? c1960]
• ISBN: 1-280-76859-2; 9786613679369; 0-470-71920-6; 0-470-71671-1
• Descrizione fisica: 1 online resource (666 p.)
• Collana: Ciba Foundation symposia
• Altri autori (Persone): VaneJohn R; O'ConnerMaeve; WolstenholmeG. E. W (Gordon Ethelbert Ward)
• Disciplina: 612.45082
• Soggetti: Adrenergic mechanisms
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: ADRENERGIC MECHANISMS; CONTENTS; Opening address; Session 1 : Formafion and lnactivation of Adrenergic Transmitters; Formation of adrenergic transmitters; Formation of adrenaline and noradrenaline; Discussion; The fate of adrenaline and noradrenaline; 3-Methoxy-4-hydroxymandelic acid excretion in phaeochromocytoma; The metabolism of [α-l4CJ](±)-adrenaline in the cat; Discussion; Session 2: Storage of Catechol Aminer; Chairman's opening remarks; Origin, development and distribution of chromaffin cells; The storage of amines in the chromaffin cell; Some observations on the synthesis and storage of catechol amines in the adrenaline-containing cells of the suprarenal medullaCell types of the adrenal medulla; Discussion; Session 3: The Adrenergic Neurone; Chairman's opening remarks; Release of sympathetic transmitter by nerve stimulation; Discussion; Interference with the release of transmitter in response to nerve stimulation; The effects of bretylium and allied agents on adrenergic neurones; The persistence of ; adrenergic nerve conduction after TM 10 or bretylium in the cat; Some pharmacological properties of guanethidine; Discussion; Session 4: Adrenergic Mechanisms in ManEffects of adrenaline, noradrenaline and isopropylnoradrenaline in man; Effects of catechol amines on consecutive vascular sections; Discussion; Clinical effects of drugs which prevent the release of adrenergic transmitter; Bretylium; Discussion; Session 5 : Actions of Adrenaline and Noradrenaline on the Effector Cell; Chairman's opening remarks: The concept of receptors; Relationships between agonists, antagonists and receptor sites; Receptors for sympathomimetic amines; Sympathomimetic drugs and their receptors; Various types of receptors for sympathomimetic drugsDiscussion; Biophysical changes produced by adrenaline and noradrenaline; Effect of adrenaline on depolarized smooth muscle; Discussion; The relation of adenosine-3',5'-phosphate to the action of catechol amines; The action of adrenaline on carbohydrate metabolism in relation to some of its pharmacodynamic efficts; Discussion; Session 6: Mechanism of Action of Other Sympathortiimetic Amines; Chairman's opening remarks; Tyramine and other amines as noradrenaline-releasing substances; Some observations on the effects of tyramine; Discussion; The actions of sympathomimetic amines on tryptamine receptorsThe depolarizing and blocking action of amphetamine in the cat's superior cervical ganglion; Discussion; Session 7: Central Adrenergic Mechanisms; Chairman's opening remarks; Some central actions of adrenaline and noradrenaline when administered into the cerebral ventricles; Intervention of an adrenergic mechanism during brain stem reticular activation; Electrophysiological evidence relating to the rôle of adrenaline in the central nervous system; The passage of catechol amines through the blood-brain barrier; Release of an adrenaline-like substance by electrical stimulation of the brain stem