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ORAL PRECANCER: DIAGNOSIS AND MANAGEMENT OF POTENTIALLY MALIGNANT DISORDERS; Contents; List of Contributors; Preface; Acknowledgements; 1 Introduction; General Introduction; Epidemiology; Prevalence of Oral Leukoplakia; Prevalence of Oral Erythroplakia; Prevention; Treatment Strategies; Terminology; Summary; References; 2 Form and Function of the Oral Mucosa; Introduction; Applied Anatomy of the Oral Cavity; Function of the Oral Mucosa; Microanatomy of the Oral Mucosa; Regional Variation of the Oral Mucosa; Oral Epithelial Cell Kinetics; Oral Epithelial Cell Proliferative Activity |
Anatomical Site Predilection for Oral CarcinogenesisSummary; References; 3 Oral Carcinogenesis; Introduction; Oral Cancer and Precancer; The 'Progression Model' for Oral Cancer; Aetiology and Risk Factors; Patient and Risk Factor Profiling; Summary; References; 4 Clinical Presentation of Oral Precancer; Introduction; Clinical Terminology; Precancerous (Premalignant) Lesions; Precancerous (Premalignant) Conditions; Syphilis; Multiple Lesion Disease; Summary; References; 5 Diagnostic Methods; Introduction; Screening; Clinical Examination Techniques; Diagnostic Aids in Precancer Diagnosis |
Brush Biopsy and Exfoliative CytologyClinical Diagnosis in Practice; Summary; References; 6 Pathological Aspects of Oral Precancer; Introduction; Biopsy Techniques; Role of the Pathologist; Histopathological Features of Oral Potentially Malignant Disorders; Grading of Dysplasia; Limitations in Conventional Pathological Techniques; Summary; References; 7 Management of Oral Precancer; Introduction; Risk Factor Modification; Observation Versus Intervention; Medical Treatment; Surgical Treatment; Combined Treatment Modalities; Patient Follow Up and Surveillance; Summary; References |
8 Clinical OutcomeIntroduction; Clinical Outcome Studies; Patient Cohort Studies; Definitions of Clinical Outcome; Newcastle Patient Cohort Studies; Patient Follow Up; Prediction of Clinical Outcome; Summary; References; 9 Malignant Transformation and Oral Cancer Development; Introduction; Risk of Progression to Oral Carcinoma; Malignant Transformation Versus Oral Cancer Development; Interventional Laser Surgery and Oral Cancer Prevention; Newcastle 10-Year Follow-Up Study; High- and Low-Risk Patients; Clinical Signs of Oral Squamous Cell Carcinoma |
Diagnosis and Management of 'Unexpected Malignancy'Prognosis for the 'Transformed' Patient; Summary; References; 10 The Future; Introduction; Prevention of Oral Precancer; Early Diagnosis of Potentially Malignant Disease; Interventional Management Strategies in the Future; Individualised Patient Treatments: Biomarkers and Targeted Chemoprevention; Future Research Directions; Summary; References; 11 Case Histories; Introduction; Case 1: Diagnosis of Unexpected Malignancy; Case 2: Multiple Lesion Disease Responding to Conservative Management |
Case 3: Multiple Lesion Disease Requiring Repeated Laser Treatments |