1.

Record Nr.

UNINA9910830425203321

Titolo

Glycogen synthase kinase 3 (GSK-3) and its inhibitors [[electronic resource] ] : drug discovery and development / / edited by Ana Martinez, Ana Castro, Miguel Medina

Pubbl/distr/stampa

Hoboken, N.J., : Wiley-Interscience, c2006

ISBN

1-280-64906-2

9786610649068

0-470-05217-1

0-470-05215-5

Descrizione fisica

1 online resource (388 p.)

Collana

Wiley series in drug discovery and development

Altri autori (Persone)

MartínezAna <1961->

CastroAna

MedinaMiguel <1959->

Disciplina

547.12

572.567

572/.567

Soggetti

Glycogen synthase kinase-3

Glycogen synthase kinase-3 - Inhibitors

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

Glycogen synthase kinase 3: an introductory synopsis -- Glycogen synthase kinase-3[beta] (GSK-3[beta]) a key signaling enzyme: a developmental neurobiological perspective -- Role of GSK-3/Shaggy in neuronal cell biology -- The crystal structures of glycogen synthase kinase 3 -- Kinase-kinase and site-site interactions in the phosphorylation of tau by GSK-3 -- GSK-3, a key player in Alzheimer's disease -- Glycogen synthase kinase 3 : a target for novel mood disorder treatments -- GSK-3 and stem cells -- Glycogen synthase kinase 3 : role in neurodegeneration and neuroprotection --

Protein kinase assays for drug discovery -- Animal models with modified expression of GSK-3 for the study of its physiology and of its implications in human pathologies -- Lithium, the seminal GSK-3 inhibitor -- Inhibition of GSK-3 as therapeutic strategy in disease : efficacy of AR-A014418 -- TDZD's: selective and ATP noncompetitive



glycogen synthase kinase 3 inhibitors -- 3-amino pyrazoles as potent and selective glycogen kinase synthase (GSK-3) inhibitors -- Marine compounds as a new source for glycogen synthase kinase 3 inhibitors.

Sommario/riassunto

Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It's a great reference for researchers in drug design and development.