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Record Nr. |
UNINA9910830418203321 |
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Titolo |
Cancer stem cells [[electronic resource] ] : identification and targets / / edited by Sharmila Bapat |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley, c2009 |
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ISBN |
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1-281-83137-9 |
9786611831370 |
0-470-39159-6 |
0-470-39156-1 |
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Descrizione fisica |
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1 online resource (274 p.) |
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Altri autori (Persone) |
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Disciplina |
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362.196/994 |
362.196994 |
616.99406 |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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CANCER STEM CELLS; CONTENTS; Contributors; Preface; 1 Cancer Stem Cells: Similarities and Variations in the Theme of Normal Stem Cells; 1.1 Introduction; 1.2 Stem Cells in the Life of an Organism; 1.2.1 Stem Cells in Early Development and Fetal Life; 1.2.2 Stem Cells in the Adult Organism; 1.3 Cancer Stem Cells; 1.3.1 Activation of Stem Cells and Cancer; 1.3.2 Isolation and Identification of Cancer Stem Cells; 1.3.3 De Novo Generation of a New Organ (Tumor) by Transformed Stem Cells; 1.4 Self-Renewal and Differentiation in CSCs |
1.5 CSC Plasticity as Regulated by Intrinsic and Extrinsic Stem Cell Factors1.5.1 Stem Cell Intrinsic Factors: Genetic and Epigenetic Effects; 1.5.2 Stem Cell Extrinsic Effects: Niche Effects and Microenvironmental Signaling; 1.6 Conclusions and Future Perspectives; References; 2 Leukemic Stem Cells; 2.1 Introduction; 2.2 Dysregulation of Hematopoiesis in Leukemia; 2.2.1 Normal Hematopoietic Stem Cell Hierarchies; 2.2.2 Understanding Aberrant Hierarchies in Leukemia; 2.2.3 Types of Leukemia; 2.3 Identification and isolation of Cancer-Initiating Cells in Leukemia |
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