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Record Nr. |
UNINA9910830291503321 |
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Titolo |
Systems biology in psychiatric research [[electronic resource] ] : from high-throughput data to mathematical modeling / / edited by Felix Tretter ... [et al.] |
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Pubbl/distr/stampa |
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Weinheim, : Wiley-VCH, 2010 |
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ISBN |
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1-282-69064-7 |
9786612690648 |
3-527-63027-9 |
3-527-63028-7 |
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Descrizione fisica |
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1 online resource (380 p.) |
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Classificazione |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Systems Biology in Psychiatric Research: From High-Throughput Data to Mathematical Modeling; Foreword; Contents; Preface; List of Contributors; Part One: Introduction; 1 Philosophical Aspects of Neuropsychiatry; 1.1 Development of Research Paradigms and Strategies in Psychiatry; 1.2 The Mind-Body Problem - Philosophy of Mind; 1.2.1 Monism and Dualism; 1.2.2 Correlation; 1.2.3 Identity Theory and its Problems; 1.2.4 Causation; 1.2.5 Supervenience; 1.3 The Conditions of Scientific Knowledge - Philosophy of Science; 1.4 Experimental Research - From Observation to Theory |
1.4.1 Hypotheses and Theory1.4.2 The ""Epistemic Cycle""; 1.4.3 Top-Down Analysis - Reductionism?; 1.4.4 Bottom-Up Explanations - Holism?; 1.5 Theoretical (Neuro)psychiatry; 1.6 Systems Thinking; 1.7 Perspectives - Towards a ""Neurophilosophy""; References; 2 Neuropsychiatry - Subject, Concepts, Methods, and Computational Models; 2.1 Introduction; 2.2 Psychiatric Fundamentals of Neuropsychiatry; 2.2.1 General Psychiatry; 2.2.2 Psychopathology; 2.2.2.1 Quantitative Psychopathology; 2.2.2.2 Theoretical Psychopathology; 2.2.3 Psychiatric Diagnoses; 2.2.3.1 Diagnostic |
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Criteria |
2.2.4 Theoretical Psychiatry2.2.4.1 ""Computational Neuropsychiatry""; 2.2.4.2 ""Systems Neuropsychiatry""; 2.3 Neurobiological Fundamentals of Neuropsychiatry; 2.3.1 Basic Findings of (Neuro)biological Psychiatry; 2.3.1.1 Neuropsychopathology; 2.3.1.2 Neurobiological Methods; 2.3.1.3 Experimental Paradigms; 2.3.1.4 Structure and Function of the Brain; 2.3.1.5 Global Circuits and their Connectivities; 2.3.1.6 Local Networks of Neurons; 2.3.1.7 Prefrontal Network in Schizophrenia; 2.3.2 Neuron; 2.3.2.1 Electrical Signaling of the Neuron; 2.3.3 Synapse; 2.3.3.1 Receptors |
2.3.4 The Cell as a System of Interacting Molecules2.3.4.1 Intracellular Signal Cascades - From Receptor to Genome; 2.3.4.2 Modeling Signal Transduction Networks Relevant in Schizophrenia; 2.3.4.3 Genomics and Proteomics; 2.3.4.4 Gene Regulation - Circular Signaling Pathways; 2.3.4.5 Systems Biology of the Neuron; 2.3.5 The Brain as a Neurochemical Oscillator; 2.3.5.1 Neurochemical Interaction Matrix; 2.3.5.2 ""Neurochemical Mobile""; 2.4 Conclusions and Perspectives; References; 3 Introduction to Systems Biology; 3.1 Introduction; 3.1.1 What is Systems Biology?; 3.1.2 Purpose of Modeling |
3.1.3 Levels of Modeling3.2 Data Analysis; 3.2.1 Types of Data; 3.2.1.1 Purification; 3.2.1.2 Detection; 3.2.1.3 Large-Scale Analyses; 3.2.1.4 Identification of Components; 3.2.2 Working with Data; 3.2.2.1 Different Clustering Approaches; 3.2.2.2 Principal Component Analysis; 3.3 ODE Modeling; 3.3.1 Differential Equations; 3.3.2 Stoichiometric Matrix; 3.3.3 Reaction Kinetics; 3.3.4 Steady States; 3.3.5 Metabolic Control Analysis; 3.3.6 Simulating Models; 3.3.7 Parameter Estimation; 3.4 Results Gained from Systems Biology; 3.4.1 Just-in-Time Transcription |
3.5 Standard Formats, Databases, and Tools |
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Sommario/riassunto |
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This first book to provide a comprehensive overview of the recent progress made in this break-through approach includes expert contributions from a variety of disciplines. Particular focus is placed on high-throughput methods and the analysis of data thus obtained, as well as their use in silico experiments so as to gain an insight into the complex biological processes in neuronal systems.A must-have for everyone working in psychiatric research. |
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