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1. |
Record Nr. |
UNINA9910453797703321 |
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Titolo |
Macular degeneration [[electronic resource] ] : causes, diagnosis and treatment / / Eddie J. Campbell and Leslie M. McMann, editors |
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Pubbl/distr/stampa |
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New York, : Nova Science Publishers, c2011 |
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ISBN |
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Descrizione fisica |
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1 online resource (165 p.) |
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Collana |
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Eye and vision research developments |
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Altri autori (Persone) |
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CampbellEddie J |
McMannLeslie M |
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Disciplina |
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Soggetti |
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Retinal degeneration |
Age factors in disease |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Correlation of phenotype and genotype in age-related macular degeneration / Henry E. Wiley, Chi-Chao Chan -- Role of anti-VEGF therapies in neovascular AMD : what the clinical trials tell us / Shripaad Y. Shukla, Daniel F. Kiernan, Jennifer I. Lim -- Surgical options for age-related macular degeneration : past, present, and future treatment options / Pradeep S. Prasad, Jean-Pierre Hubschman -- Emerging new rationale for the treatment of pathogenic retina based on molecular genetic and biochemical studies / Barkur S. Shastry -- Ocular blood flow in degenerative myopia / Galina Dimitrova, Satoshi Kato -- Hereditary and age-related macular degeneration / Nancy Skoura, Josephine Hoh, Ju Liu -- Cigarette smoke and hypertension : two risk factors for age-related macular degeneration / Maria Marin-Castano -- Nanotechnology-based drug delivery system in treating age-related macular degeneration / Yasuhiro Tamaki -- Macular degeneration / Peter Francis. |
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2. |
Record Nr. |
UNINA9910830153503321 |
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Titolo |
Modeling solvent environments [[electronic resource] ] : applications to simulations of biomolecules / / edited by Michael Feig |
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Pubbl/distr/stampa |
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Weinheim, : Wiley-VCH Verlag GmbH, c2010 |
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ISBN |
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1-282-47232-1 |
9786612472329 |
3-527-62925-4 |
3-527-62926-2 |
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Descrizione fisica |
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1 online resource (336 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Modeling Solvent Environments: Applications to Simulations of Biomolecules; Contents; Preface; List of Contributors; 1: Biomolecular Solvation in Theory and Experiment; 1.1 Introduction; 1.2 Theoretical Views of Solvation; 1.2.1 Equilibrium Thermodynamics of Solvation; 1.2.2 Radial Distribution Functions; 1.2.3 Integral Equation Formalisms; 1.2.4 Kirkwood-Buff Theory; 1.2.5 Kinetic Effects of Solvation; 1.3 Computer Simulation Methods in the Study of Solvation; 1.3.1 Molecular Dynamics and Monte Carlo Simulations; 1.3.2 Water Models; 1.3.3 Solvent Structure and Dynamics from Simulations |
1.3.4 Free Energy Simulations1.4 Experimental Methods in the Study of Solvation; 1.4.1 X-Ray/Neutron Diffraction and Scattering; 1.4.2 Nuclear Magnetic Relaxation; 1.4.3 Optical Spectroscopy; 1.4.4 Dielectric Dispersion; 1.5 Hydration of Proteins; 1.5.1 Protein Folding and Peptide Conformations in Aqueous Solvent; 1.5.2 Molecular Properties of Water Near Protein Surfaces; 1.5.3 Water Molecules at Protein-Ligand and Protein-Protein Interfaces; 1.6 Hydration of Nucleic acids; 1.7 Non-Aqueous Solvation; 1.7.1 Alcohols; 1.7.2 Urea; 1.7.3 Glycerol; 1.8 Summary; References |
2: Model-Free "Solvent Modeling" in Chemistry and Biochemistry Based |
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on the Statistical Mechanics of Liquids2.1 Introduction; 2.2 Outline of the RISM and 3D-RISM theories; 2.3 Partial Molar Volume of Proteins; 2.4 Detecting Water Molecules Trapped Inside Protein; 2.5 Selective Ion Binding by Protein; 2.6 Water Molecules Identified as a Substrate for Enzymatic Hydrolysis of Cellulose; 2.7 CO Escape Pathway in Myoglobin; 2.7.1 Effect of Protein Structure on the Distribution of Xe; 2.7.2 Partial Molar Volume Change Through the CO Escape Pathway of Myoglobin; 2.8 Perspective; References |
3: Developing Force Fields From the Microscopic Structure of Solutions: The Kirkwood-Buff Approach3.1 Introduction; 3.2 Biomolecular Force Fields; 3.3 Examples of Problems with Current Force Fields; 3.4 Kirkwood-Buff Theory; 3.5 Applications of Kirkwood-Buff Theory; 3.6 The General KBFF Approach; 3.7 Technical Aspects of the KBFF Approach; 3.8 Results for Urea and Water Binary Solutions; 3.9 Preferential Interactions of Urea; 3.10 Conclusions and Future Directions; Acknowledgments; References; 4: Osmolyte Influence on Protein Stability: Perspectives of Theory and Experiment; 4.1 Introduction |
4.2 Denaturing Osmolytes4.2.1 Does Urea Weaken Water Structure?; 4.2.2 Effect of Urea on Hydrophobic Interactions; 4.2.3 Direct Interaction of Urea with Proteins; 4.3 Protecting Osmolytes; 4.3.1 Do Protecting Osmolytes Increase Water Structure?; 4.3.2 Effect of Protecting Osmolytes on Hydrophobic Interactions; 4.4 Mixed Osmolytes; 4.5 Conclusions; Acknowledgments; References; 5: Modeling Aqueous Solvent Effects through Local Properties of Water; 5.1 The Role of Water and Cosolutes on Macromolecular Thermodynamics; 5.2 Forces Induced by Water in Aqueous Solutions |
5.2.1 Interactions in Water-Accessible Regions of Proteins |
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Sommario/riassunto |
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A comprehensive view of the current methods for modeling solvent environments with contributions from the leading researchers in the field. Throughout, the emphasis is placed on the application of such models in simulation studies of biological processes, although the coverage is sufficiently broad to extend to other systems as well. As such, this monograph treats a full range of topics, from statistical mechanics-based approaches to popular mean field formalisms, coarse-grained solvent models, more established explicit, fully atomic solvent models, and recent advances in applying ab initio me |
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