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1. |
Record Nr. |
UNINA9910467804803321 |
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Autore |
Collier Bruce |
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Titolo |
Charles Babbage and the engines of perfection / / Bruce Collier and James MacLachlan |
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Pubbl/distr/stampa |
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New York ; ; Oxford : , : Oxford University Press, , [1998] |
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©1998 |
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ISBN |
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Descrizione fisica |
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1 online resource (123 pages) : illustrations |
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Collana |
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Oxford portraits in science |
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Disciplina |
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Soggetti |
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Mathematicians - England |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Charles Babbage, the grandfather of the modern computer, did not live to see even one of his calculating machines at work. A dazzling genius with vision extending far beyond the limitations of the Victorian age, Babbage successfully calculated a table of logarithms during his years at Cambridge University, allowing mathematical calculations to be executed with extreme precision. Only the possibility of human error prevented complete accuracy, and Babbage understood that the only way to attain perfection is to leave the human mind entirely out of the equation. He devoted most of his life and spent most of his private fortune and government stipend trying to improve his difference engines and analytical engines. Bruce Collier and James MacLachlan chronicle Babbage's education and scientific career, his remarkably active social life and long string of personal tragedies, his forays into philosophy and economics, his successes and failures, and the biggest disappointment of his life-- his ingenious inventions were centuries ahead of the primitive capabilities of Victorian technology. Oxford Portraits in Science is an on-going series of scientific biographies for young adults. Written by top scholars and writers, each biography examines the personality of its subject as well as the thought process leading to his or her discoveries. These illustrated biographies combine |
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accessible technical information with compelling personal stories to portray the scientists whose work has shaped our understanding of the natural world. |
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2. |
Record Nr. |
UNINA9910830060603321 |
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Titolo |
Pseudo-peptides in drug discovery [[electronic resource] /] / [edited by] Peter E. Neilsen |
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Pubbl/distr/stampa |
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Weinheim, : Wiley-VCH, c2004 |
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ISBN |
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1-280-52069-8 |
9786610520695 |
3-527-60569-X |
3-527-60190-2 |
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Descrizione fisica |
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1 online resource (258 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Peptide drugs - Design |
Peptides |
Amino acids - Synthesis |
Polyamides |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Pseudo-peptides in Drug Discovery; Contents; Preface; List of Contributors; 1 Versatile Oligo(N-Substituted) Glycines: The Many Roles of Peptoids in Drug Discovery; 1.1 Introduction; 1.2 Peptoid Synthesis; 1.2.1 Solid-Phase Synthesis; 1.2.2 Sub-monomer Solid-Phase Method; 1.2.3 Side Reactions; 1.2.4 Post-Synthetic Analysis; 1.3 Drug Discovery via Small-Molecule Peptoid Libraries; 1.3.1 Peptoid Drugs from Combinatorial Libraries; 1.3.2 Peptoid Inhibitors of RNA-Protein Interactions; 1.4 Peptoid-Based Drug Delivery and Molecular Transporters: Cellular Uptake |
1.4.1 Peptoid Mimics of HIV-Tat Protein1.4.2 Cellular Delivery of Nucleic Acids; 1.5 Peptoid Mimics of Peptide Ligands; 1.6 Peptoids with Folded Structure; 1.6.1 Restricting Conformational Space; 1.6.2 Peptoid |
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Helices; 1.6.2.1 CD and NMR Studies of a Helical Peptoid Pentamer with α-Chiral Aromatic Side Chains; 1.6.2.2 CD Studies of Longer Peptoid Helices Containing α-Chiral Aromatic Side Chains; 1.6.2.3 Structural Studies of Peptoids with Aliphatic Side Chains by CD, NMR, and X-ray Crystallography; 1.6.2.4 Summary; 1.6.3 Protein-mimetic Structures |
1.7 Biomimetic Peptoid Structures for Therapeutic Applications1.7.1 Peptoid Mimics of Antibacterial Peptides; 1.7.2 Peptoid-Based Mimics of Lung Surfactant Proteins; 1.7.3 Collagen-based Structures Containing Peptoid Residues; 1.8 Obstacles to the Development of Biomedically-useful Peptoids; 1.8.1 Enhance the Diversity of Secondary Structure in Peptoid Foldamers; 1.8.2 Improve Understanding of Peptoid Sequence/Structure Relationships; 1.8.3 Translate Bioactive Peptide Sequences into Bioactive Peptoid Sequences; 1.8.4 Develop Peptoids with Stable Tertiary Structure |
1.8.5 Develop Peptoid Shuttles for Intracellular Import of Xenobiotic Agents1.8.6 Optimize Pharmacological Profile of Oligopeptoids; 1.9 Conclusion; 1.10 References; 2 β-Peptides, γ-Peptides and Isosteric Backbones: New Scaffolds with Controlled Shapes for Mimicking Protein Secondary Structure Elements; 2.1 Introduction; 2.2 Molecular Organization in β-Peptide Oligomers; 2.2.1 Historical Background; 2.2.2 β-Amino Acids versus α-Amino Acids: An Enormous Increase in Chemical Diversity; 2.2.3 Helical Folds; 2.2.3.1 The 3(14)-Helix; 2.2.3.2 The 12/10- (10/12-) Helix; 2.2.3.3 The 2.5(12)-Helix |
2.2.3.4 The 2(8)-Helix2.2.4 Extended β-Peptide Strands, Turns and Formation of Sheet Structures; 2.3 Molecular Organization in γ-Peptide Oligomers; 2.3.1 Preparation of γ-Amino Acid Monomers for γ-Peptide Synthesis; 2.3.2 Helical Folds; 2.3.3 Turn and Sheet Structures; 2.4 Biological Activities of β- and γ-Peptides; 2.4.1 Biological Stability; 2.4.2 Bioactive Peptides Based on Helical Scaffolds; 2.4.3 Bioactive Peptides Based on Open-Chain β-Turn Mimetics; 2.4.4 Cell Penetrating β-Peptides; 2.5 Isosteres; 2.5.1 Example 1: Oligomers of α-Aminooxy Acids as β-Peptide Mimetics |
2.5.2 Example 2: N,N ́-Linked Oligoureas as γ-Peptide Mimetics |
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Sommario/riassunto |
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Peptides are among the most versatile bioactive molecules, yet the do not make good drugs, because they are quickly degraded or modified in the body.To overcome this problem, stable and at the same time biologically active pseudo-peptides have been developed. These novel compounds open up new perspectives in drug design by providing an entire range of highly specific and non-toxic pharmaceuticals.This is the first work devoted to the topic and draws together knowledge gained on different types of peptidomimetics and other pseudo-peptides with drug properties. As such, it includes pepto |
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