| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910829806603321 |
|
|
Titolo |
Recent advances in polyphenol research . Volume 8. / / edited by Juha-Pekka Salminen [and three others] |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Hoboken, New Jersey : , : John Wiley & Sons, , [2023] |
|
©2023 |
|
|
|
|
|
|
|
|
|
ISBN |
|
1-119-84479-7 |
1-119-84478-9 |
1-119-84477-0 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (413 pages) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Cover -- Title Page -- Copyright Page -- Dedications -- Contents -- Contributors -- Preface -- Acknowledgments -- Chapter 1 Lignins and Lignification: New Developments and Emerging Concepts -- 1.1 Introduction -- 1.2 The Monolignol Pathway and Interacting Pathways - New Lignins -- 1.2.1 Truncated Monolignol Biosynthesis -- 1.2.2 Phenolics from Beyond the Monolignol Biosynthetic Pathway -- 1.2.3 Lignin Design, and the Concept of an Ideal Lignin -- 1.3 Lignin Conjugates, "Clip-Offs' - New Discoveries, and Enhancing Levels -- 1.3.1 Clip-Offs and Their Elevation -- 1.3.2 Exploring Monolignol Conjugates in Compositionally Extreme Lignins -- 1.4 Features of Lignification and the Possibility of New Polymerization Pathways -- 1.4.1 Features of Lignification -- 1.5 The Case for Model Studies and Synthesis -- 1.5.1 The Value of Proper Low-Molecular-Mass Model Compounds -- 1.5.2 Synthetic Lignin Polymers, Dehydrogenation Polymers (DHPs) -- 1.6 New or Improved Analytics -- 1.7 Conclusions and Opportunities -- Acknowledgments -- References -- Chapter 2 Synthesis of Epigallocatechin Gallate, Nobiletin, and Their Derivatives for Chemical-Biological Studies -- 2.1 Synthetic Investigations of Catechin Derivatives -- 2.2 Synthesis and Application of Fluorescent Catechin Probes -- 2.3 Generation of Catechin Antibody -- 2.4 PET Imaging of Biodistribution of Catechin -- 2.5 Practical Synthesis |
|
|
|
|
|
|
|
|
|
of Nobiletin -- 2.6 Derivatization of Desmethyl Nobiletins -- 2.7 PET Imaging of Biodistribution of Nobiletin -- 2.8 Synthesis and Application of Fluorescent Nobiletin Probe -- 2.9 Conclusions -- References -- Chapter 3 Procyanidins in the Onset and Progression of Colorectal Cancer: Recent Advances and Open Questions -- 3.1 Introduction -- 3.2 Procyanidins: Chemistry and Metabolism -- 3.3 Procyanidins and CRC: Epidemiological Evidence -- 3.4 Procyanidins and CRC: Rodent Studies. |
3.5 Procyanidins and CRC: Mechanisms of Action -- 3.5.1 Interactions with Membranes -- 3.5.2 Inflammation and the NF-B Pathway -- 3.5.3 EGFR and IGF1R Pathways -- 3.6 Conclusions and Open Questions -- Acknowledgments -- Conflict of Interest Disclosure -- References -- Chapter 4 The Potential of Low Molecular Weight (Poly)phenol Metabolites for Attenuating Neuroinflammation and Treatment of Neurodegenerative Diseases -- 4.1 Introduction: Neurodegenerative Disorders, Dietary (Poly)phenols and Neuroinflammation -- 4.2 (Poly)phenols: Metabolism and Distribution -- 4.3 (Poly)phenol Metabolites and Their Brain Permeability -- 4.4 LMW (Poly)phenol Metabolites as Effectors for Attenuating Neuroinflammation -- 4.5 Concluding Remarks -- Acknowledgments -- References -- Chapter 5 Deciphering Complex Natural Mixtures through Metabolome Mining of Mass Spectrometry Data: The Plant Specialized Metabolome as a Case Study -- 5.1 Introduction -- 5.2 Materials and Methods -- 5.2.1 Case Studies -- 5.2.2 Metabolome Mining Tools -- 5.2.3 Metabolome Annotation Tools -- 5.3 Results and Discussion -- 5.3.1 Rhamnaceae Case Study -- 5.3.2 Euphorbia Case Study -- 5.3.3 Pepper Case Study -- 5.3.4 Other Plant Metabolomics Studies -- 5.4 Current Limitations -- 5.5 Conclusions -- 5.6 Outlook -- 5.6.1 Extended Natural Product Candidate Structure Space -- 5.6.2 Improved Mass Spectral Similarity Scoring -- 5.6.3 Combined Genome and Metabolome Analyses -- 5.6.4 Linking Complementary Analytical Tools -- 5.6.5 Future Perspective: Chemically Informed Repository-Scale Analyses -- Acknowledgments -- References -- Chapter 6 Application of MS-Based Metabolomics to Investigate Biomarkers of Apple Consumption Resulting from Microbiota and Host Metabolism Interactions -- 6.1 Introduction -- 6.2 Materials and Methods -- 6.2.1 Acute Intake Study -- 6.2.2 Long-Term Intake Study. |
6.2.3 Metabolomic Analysis -- 6.2.4 Data Processing and Statistical Analysis -- 6.2.5 Metabolomic Data Sharing -- 6.3 Results and Discussion -- 6.3.1 Lessons from the Acute Study -- 6.3.2 Lessons from the Prolonged Exposure Study -- 6.4 Conclusion -- Acknowledgments -- Funding -- References -- Chapter 7 Non-Extractable Polyphenols Should be Systematically Included in Polyphenol Analysis -- 7.1 Introduction: The Concept of Non-Extractable Polyphenols -- 7.2 Analysis of Non-Extractable Polyphenols -- 7.2.1 Preparation of Solutions of Non-Extractable Polyphenols -- 7.2.2 Analysis of the Profile of NEPP -- 7.2.3 Determination of the Content of Non-Extractable Polyphenols. Which Standard? -- 7.2.4 Analysis of Dietary Fiber: Connection with Non-Extractable Polyphenols -- 7.3 Why Should Non-Extractable Polyphenols be Systematically Included in Polyphenol Analysis? -- 7.3.1 Intake of NEPP in Different Populations -- 7.3.2 Metabolism of NEPP -- 7.3.3 Beneficial Effects Attributed to NEPP -- 7.4 Relevance of the Determination of Non-Extractable Polyphenols in Quality Control -- 7.4.1 Comprehensive Characterization of Vegetal Materials -- 7.4.2 Identification of New Botanical Sources with Potential Applications -- 7.4.3 Comparison Between Varieties -- 7.4.4 Evaluation of Processing Effects -- 7.5 Perspectives -- References -- Chapter 8 Template-Mediated |
|
|
|
|
|
|
|
|
Engineering of Functional Metal-Phenolic Complex Coatings -- 8.1 Introduction -- 8.2 Template-Mediated Techniques to Deposit MPNs -- 8.3 MPN Film Properties -- 8.4 MPN Surface Interactions and Applications -- 8.5 Upscaling Considerations and Challenges -- 8.5.1 Reagent Considerations -- 8.5.2 Engineering Controls -- 8.5.3 Washing and Solvents -- 8.5.4 Human Resources and Training -- 8.5.5 Environmental Health and Safety Considerations -- 8.6 Method Automation: Possibilities and Outlook. |
8.6.1 Automated Assembly Techniques -- 8.7 Conclusions -- References -- Chapter 9 Highly Efficient Production of Dihydroflavonol 4-Reductases in Tobacco Cells and Refinement of the BuOH-HCl Enzymatic Assay -- 9.1 Introduction -- 9.2 Results -- 9.2.1 Transient Expression from Hypertranslatable Vectors -- 9.2.2 BuOH-HCl Assay Revisited -- 9.2.3 Substrate Profiles of Different DFRs -- 9.3 Materials and Methods -- 9.3.1 Plant Material and Chemicals -- 9.3.2 Isolation of DFR Encoding Sequences and Plasmid Construction -- 9.3.3 Protein Extraction and Purification -- 9.3.4 BuOH-HCl Assay -- 9.3.5 HPLC -- 9.4 Discussion -- Acknowledgements -- References -- Chapter 10 A Long and Winding Road: The Evolution of Transcriptional Regulation of Polyphenol Biosynthesis -- 10.1 Introduction -- 10.2 The Importance of R2R3Myb Transcription Factors (TFs) in the Regulation of Phenylpropanoid Metabolism in Plants -- 10.2.1 R2R3Myb TFs Regulate Specialized Branches of Polyphenol Metabolism -- 10.2.2 R2R3Myb Transcriptional Repressors Controlling Phenylpropanoid Metabolism -- 10.2.3 Stand-Alone R2R3Myb Transcriptional Activators -- 10.2.4 R2R3Myb TFs Working in MBW Complexes to Regulate Phenylpropanoid Metabolism -- 10.3 The Role of bHLH Proteins in the Regulation of Phenylpropanoid Metabolism -- 10.3.1 Roles of bHLH-1 and bHLH-2 Clades in RegulatingAnthocyanin Biosynthesis -- 10.3.2 Roles of bHLH-1 and bHLH-2 Clades in the Regulation of Proanthocyanidin Biosynthesis -- 10.4 The Role of the WDR in the MBW Complex in the Regulation of Polyphenol Metabolism -- 10.5 Additional Factors Regulating Transcriptional Controlof the MBW Complex -- 10.6 Conclusions -- Acknowledgments -- References -- Chapter 11 Analysis of Proanthocyanidins in Food Ingredients by the 4-(Dimethylamino)cinnamaldehyde Reaction -- 11.1 Introduction. |
11.2 Background on the 4-(Dimethylamino)cinnalmaldehyde (DMAC) Reaction with PACs -- 11.3 Mechanism of the Acid-Catalyzed DMAC Reaction with PACs -- 11.4 Absorption and Emission Spectra of the DMAC Reaction Products -- 11.5 Standards for the DMAC Reaction and Accuracy of the Method -- 11.6 Interaction of PAC-DMAC Reaction Products with Extra-Intestinal Pathogenic Escherichia coli -- 11.7 Conclusion -- References -- Chapter 12 Reactions of Ellagitannins Related to Their Metabolism in Higher Plants -- 12.1 Introduction -- 12.2 Structural Variety of Ellagitannin Acyl Groups -- 12.3 Reactions of the DHHDP Group -- 12.4 Decomposition of 1,4-DHHDP--d-glucose -- 12.5 Amariin as a Precursor of Geraniin -- 12.6 Triterpenoid HHDP Esters in Castanopsis sieboldii -- 12.7 Highly Oxidized Ellagitannins in Carpinus japonica -- 12.8 Similarity of Catechin Oxidation to Oxidation of Methyl Gallate -- 12.9 Production Mechanism of DHHDP and HHDP -- 12.10 Oxidative Degradation of Ellagitannins -- 12.10.1 Degradation of Pedunculagins in the Leaves of Common Camellia Species -- 12.10.2 Degradation of Vescalagin in the Leaves of Japanese Blue Oak -- 12.10.3 Degradation of Vescalagin with Wood-Decaying Fungi -- 12.11 Conclusions -- References -- Index -- EULA. |
|
|
|
|
|
| |