1.

Record Nr.

UNINA9910827674403321

Titolo

Connexin cell communication channels : roles in the immune system and immunopathology / / edited by Ernesto Oviedo-Orta, Brenda R. Kwak, William Howard Evans

Pubbl/distr/stampa

Boca Raton, Fla., : CRC Press, c2013

Boca Raton : , : Taylor & Francis/CRC Press, , 2013

ISBN

9781040212318

104021231X

9780429165856

0429165854

9781439862582

1439862583

Edizione

[1st ed.]

Descrizione fisica

1 online resource (363 p.)

Altri autori (Persone)

Oviedo-OrtaErnesto

KwakBrenda R

EvansW. Howard

Disciplina

591.876041

Soggetti

Gap junctions (Cell biology)

Connexins

Inflammation

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references.

Nota di contenuto

Front Cover; Contents; Preface; Editors; Contributors; Prequel: Gap Junctions, Hemichannels, and Cell-to-Cell Signalling; Chapter 1 - Communication in the Immune System by Connexin Channels; Chapter 2 - Gap Junctions and Connexins in the Hematopoietic-Immune System: Structural Considerations; Chapter 3 - Approaches for Studying the Role(s) of Gap Junctions in the Immune System; Chapter 4 - Gap Junctions in Antigen-Presenting Cells; Chapter 5 - Connect the Immune System: Roles of Gap Junctions in Antigen Presentation and T Cell Activation

Chapter 6 - Gap Junctions and Connexins in the Immune Defense Against TumorsChapter 7 - Connexins in Atherosclerosis; Chapter 8 -



Connexins in Lung Function and Inflammation; Chapter 9 - Effect of Oxidative Stress on Connexins in the Vasculature; Chapter 10 - Regulation of Gap Junctions and Cellular Coupling within the Microvasculature in Response to Acute Inflammation; Chapter 11 - Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation; Chapter 12 - A Role for Connexins in Inflammatory Disorders of the Epidermis

Chapter 13 - Translating Basic Research on Cx43 Gap Junctions into Therapies for Reducing Scarring and Cardiac ArrhythmiaChapter 14 - Connexin-Based Therapeutic Approaches to Inflammation in the Central Nervous System; Chapter 15 - Enhancing Epithelial Tissue Repair and Reducing Inflammation by Targeting Connexins; Back Cover

Sommario/riassunto

Plasma membrane-associated channels known as gap junctions, along with their protein building blocks-connexins-have an important functional role in a range of immunological processes, including heart function, cell growth and specialization, and early development. Spanning basic science and potential clinical applications, Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology assembles and synthesizes four decades of the most important research carried out in this field. The book first provides a historical overview of the discovery of these membrane channels in