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Record Nr. |
UNINA9910691698503321 |
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Autore |
Dacey Robert F |
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Titolo |
Information security [[electronic resource] ] : weaknesses place commerce data and operations at serious risk : statement of Robert F. Dacey, Director, Information Security Issues, before the Subcommittee on Oversight and Investigations, Committee on Energy and Commerce, House of Representatives / / United States General Accounting Office |
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Pubbl/distr/stampa |
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[Washington, D.C.] : , : The Office, , [2001] |
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Collana |
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Testimony ; ; GAO-01-1004 T |
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Soggetti |
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Computer security - United States |
Electronic information resources - Access control - United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"For release ... August 3, 2001." |
Paper version available from the General Accounting Office. |
Title from title screen. |
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Nota di bibliografia |
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Includes bibliographical references. |
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2. |
Record Nr. |
UNINA9910829843303321 |
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Titolo |
Catalytic antibodies [[electronic resource] /] / edited by Ehud Keinan |
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Pubbl/distr/stampa |
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Weinheim, : Wiley-VCH |
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[Chichester, : John Wiley], 2005 |
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ISBN |
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1-280-52020-5 |
9786610520206 |
3-527-60366-2 |
3-527-60505-3 |
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Descrizione fisica |
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1 online resource (618 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Monoclonal antibodies |
Antibody-enzyme conjugates |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Catalytic Antibodies; Foreword; Table of Contents; Preface; List of Contributors; 1 Immunological Evolution of Catalysis; 1.1 Introduction; 1.2 Parallels between Antibody and Enzyme Evolution; 1.3 Evolution of Catalytic Antibodies; 1.4 Ferrochelatase Antibody 7G12 - Evolution of the Strain Mechanism; 1.5 Esterase Antibody 48G7 - Effect of Distant Mutations on Catalysis; 1.6 Sulfur Oxidase Antibody 28B4 - Incremental Changes in Evolution; 1.7 Oxy-Cope Antibody AZ28 - Evolution of Conformational Diversity in Catalysis |
1.8 Diels-Alderase Antibody 39A11 - Evolution of a Polyspecific Antibody combining Site1.9 Conclusions; References; 2 Critical Analysis of Antibody Catalysis; 2.1 Introduction; 2.2 Exploiting Antibodies as Catalysts; 2.3 Catalytic Efficiency; 2.4 Hapten Design; 2.5 Representative Catalytic Antibodies; 2.5.1 Proximity Effects; 2.5.1.1 Sigmatropic Rearrangements; 2.5.1.2 Cycloadditions; 2.5.2 Strain; 2.5.2.1 Ferrochelatase Mimics; 2.5.2.2 Other Systems; 2.5.3 Electrostatic Catalysis; 2.5.3.1 Acyl Transfer Reactions; 2.5.4 Functional Groups; 2.5.4.1 Aldolases; 2.6 Perspectives |
2.6.1 General Lessons from Comparisons of Enzymes and Antibodies2. |
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6.2 How efficient does catalysis need to be?; 2.6.3 Strategies for Optimizing Efficiency; 2.6.3.1 Better Haptens; 2.6.3.2 Screening; 2.6.3.3 Engineering; 2.6.3.4 Selection; 2.6.3.5 Other Scaffolds; 2.7 Conclusions; References; 3 Theoretical Studies of Antibody Catalysis; 3.1 Introduction; 3.2 Questions Subject to Theoretical Elucidation; 3.2.1 Predicting Antibody Structure from Sequence; 3.2.2 Predicting Binding Modes and Binding Energies; 3.2.3 Understanding Antibody Catalysis [14]; 3.2.4 General Considerations |
3.3 Hydrolytic Antibodies3.3.1 Gas and Solution Phase Hydrolysis of Aryl Esters; 3.3.2 Hapten Fidelity; 3.3.3 Theoretical Exploration of Antibody Catalysis; 3.3.3.1 16G3; 3.3.3.2 6D9; 3.3.3.3 43C9; 3.3.3.4 CNJ206; 3.3.3.5 48G7; 3.3.3.6 17E8 and 29G11; 3.4 Cationic Cyclizations; 3.4.1 Antibody Catalysis of Solvolysis; 3.4.2 Antibody-Catalyzed Hydroxyepoxide Cyclization; 3.5 Antibody-Catalyzed Diels-Alder and retro-Diels-Alder Reactions; 3.5.1 The Most Efficient endo-Diels-Alderase 1E9; 3.5.2 endo-Diels-Alderase 39A11 and its Germline Precursor; 3.5.3 exo-Diels-Alderase 13G5 |
3.5.4 retro-Diels-Alderase 10F113.6 Other Antibody-Catalyzed Pericyclic Reactions; 3.6.1 Oxy-Cope Rearrangement Catalyzed by Antibody AZ-28; 3.6.2 1,3-Dipolar Cycloaddition Catalyzed by Antibody 29G12; 3.6.3 Chorismate-Prephenate Claisen Rearrangement Catalyzed by Antibody 1F7; 3.7 Antibody-Catalyzed Carboxybenzisoxazole Decarboxylation; 3.8 Summary; References; 4 The Enterprise of Catalytic Antibodies: A Historical Perspective; 4.1 Introduction; 4.2 Methods; 4.3 Results; 4.3.1 The Conceptual Origins of Catalytic Antibodies; 4.3.2 Tapping the Immune System for Catalysts; 4.4 Conclusions |
References |
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Sommario/riassunto |
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Exploiting the inherent combinatorial mechanism in the biosynthesis of antibodies, an almost limitless variety of biocatalysts may be generated. Catalytic antibodies are capable of performing almost any type of reaction with high selectivity and stereospecificity.Here, the pioneers in the use of catalytic antibodies review the entire scope of this interdisciplinary field, covering such topics as:* theoretical aspects of structure, mechanism and kinetics* practical considerations, from immunization techniques to screening methods* in vitro evolution and other modern approaches<b |
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3. |
Record Nr. |
UNINA9910827564603321 |
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Titolo |
Mathematical results in quantum mechanics : a conference on QMATH-8, mathematical results in quantum mechanics, Universidad Nacional Autonoma de México, Taxco, México, December 10-14, 2001 / / Ricardo Weder, Pavel Exner, Benoit Grébert, editors |
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Pubbl/distr/stampa |
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Providence, Rhode Island : , : American Mathematical Society, , [2002] |
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©2002 |
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ISBN |
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0-8218-7897-2 |
0-8218-2900-9 |
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Descrizione fisica |
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1 online resource (362 p.) |
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Collana |
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Contemporary mathematics, , 0271-4132 ; ; 307 |
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Disciplina |
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Soggetti |
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Quantum theory - Mathematical models |
Mathematical physics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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""A semiclassical approach in linear response theory""""Wigner-von Neumann-like potentials""; ""Equilibrium potentials in scattering theory""; ""Straight quantum waveguides with combined boundary conditions""; ""Perturbation theory for the quantum time-evolution in rotating potentials""; ""Two dimensional Pauli operator via scalar potential""; ""A max-min principle for the ground state of the Dirac-Fock functional""; ""On the regularity of the density of electronic wave functions""; ""Enhanced binding through coupling to a photon field"" |
""The large radius limit for coherent states on spheres""""Quantum scattering for potentials homogeneous of degree zero""; ""Existence of the density of states for one-dimensional alloy-type potentials with small support""; ""Statistical ensembles and density of states""; ""The Cauchy problem for the Toda lattice with a class of non-stabilized initial data""; ""Absolutely continuous spectrum of Jacobi matrices""; ""Stability of matter in relativistic quantum electrodynamics""; ""The algebra of observables in a magnetic field"" |
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