| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910826531303321 |
|
|
Titolo |
Telomerases : chemistry, biology, and clinical applications / / edited by Neal F. Lue, Chantal Autexier |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Hoboken, N.J., : Wiley, 2012 |
|
|
|
|
|
|
|
ISBN |
|
1-280-76873-8 |
9786613679505 |
1-118-26751-6 |
1-118-26866-0 |
1-118-26850-4 |
|
|
|
|
|
|
|
|
Edizione |
[1st. ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (336 p.) |
|
|
|
|
|
|
Altri autori (Persone) |
|
LueNeal F. <1962-> |
AutexierChantal <1963-> |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
The telomerase complex : an overview / Johanna Mancini and Chantal Autexier -- Telomerase RNA : structure, function, and molecular mechanisms / Yehudi Tzfati and Julian J.-L. Chen -- TERT structure, function, and molecular mechanisms / Emmanuel Skordalakes and Neal F. Lue -- Telomerase biogenesis : RNA Processing, trafficking and protein Interactions / Tara Beattie and Pascal Chartrand -- Transcriptional regulation of human telomerase / Antonella Farsetti and Yu-Sheng Cong -- Telomerase regulation and telomere length homeostasis / Joachim Lingner and David Shore -- Telomere structure in telomerase regulation / Momchil D. Vodenicharov and Raymund J. Wellinger -- Off-telomere functions of telomerase / Kenkichi Masutomi and William C. Hahn -- Murine Models of Dysfunctional Telomeres and Telomerase / Yie Liu and Lea Harrington -- Cellular senescence, telomerase, and cancer in human cells / Phillip G. Smiraldo ... [et al.] -- Telomerase, retrotransposons, and evolution / Irina R. Arkhipova. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
"This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the |
|
|
|
|
|
|
|
|
|
|
essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed"--Provided by publisher. |
|
|
|
|
|
| |