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Record Nr. |
UNINA9910826508603321 |
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Titolo |
Epigenetics : current research and emerging trends / / edited by Brian P. Chadwick |
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Pubbl/distr/stampa |
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Norfolk, England : , : Caister Academic Press, , [2015] |
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©2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (368 p.) |
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Disciplina |
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Soggetti |
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Epigenesis |
Genetic regulation |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents; Contributors; Preface; 1: The Multifaceted Roles of YY1 in the Establishment of the Cellular Epigenetic Landscape; Introduction; YY1; YY1 and the polycomb pathway; YY1 and genomic imprinting; YY1 and the inactivation of the X-chromosome; YY1 and heterochromatin establishment during spermatogenesis; Regulation of YY1; YY1 and cancer; Conclusions; 2: SETting up the Epigenome Through the Histone Methyltransferase SETDB1; SETting the stage; Histone methyltransferases; SETDB1 interacting proteins; SETDB1 in development; SETDB1 and ERVs; SETDB1 and disease; Concluding remarks |
3: Sirtuin Deacetylases in Fungi: Connecting Metabolism to Lifecycle Progression, Stress Response and Genome StabilityProperties of sirtuins; Subfamilies of sirtuins; Contributions of sirtuins to fungal biology; 4: Development-linked Differences in Cytosine 5-Hydroxymethylation in Mammalian DNA: Relationship to 5-Methylcytosine and Function; Introduction; Analytic methods used to study 5hmC in vertebrate DNA; DNA hydroxymethylation in very early mammalian development: embryonic stem cells (ESC); DNA hydroxymethylation changes during development: neurogenic, germline and adipogenic lineages |
5hmC in a variety of other tissue typesMyogenic differential DNA methylation, 5hmC, and comparisons of 5hmC and 5mC levels; 5hmC |
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versus 5mC: chromatin modifications, transcription factors, DNA strand biases and proposed functions; DNA hydroxymethylation and methylation: cellular heterogeneity and dynamics; Conclusions; 5: The Identification of Mammalian Proteins Involved in Epigenetics; Lessons from position effect variegation in Drosophila and yeast; Finding modifiers of PEV in mammals; Known modifier genes identified in the MommeD screen |
Momme genes not previously linked to epigenetic regulation of transcriptionOther types of genetic screens for factors involved in epigenetic function; Yeast two-hybrid screens can identify novel epigenetic regulators; Affinity purification of proteins involved in epigenetics; Affinity purification of DNA elements, telomeres and repetitive loci and single loci; Concluding remarks; 6: Chromatin-mediated Response to Stimuli; Introduction to chromatin structure; Determinates of nucleosome position; History of dynamic chromatin structure; Recent advances in mapping nucleosome dynamics |
Genome-scale nucleosome mapping and dynamicsThe role of nucleosome position and sensitivity in genome regulation; A hierarchical model for genome response; Conclusions; 7: The Epigenetics of Centromere Function; Introduction; Centromeric chromatin and the histone variant CENP-A; Dicentric chromosomes and centromere inactivation; Artificial chromosomes; Neocentromeres and ectopic/induced centromeres; RNA, transcription, and centromere function; Concluding remarks; 8: Dosage Compensation in Frogs and Toads; Introduction to gene dosage and dosage compensation; What is dosage compensation? |
Genetic sex determination, sex chromosomes and dosage compensation |
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Sommario/riassunto |
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Epigenetics can have a significant impact on human health and disease susceptibility. Over the past few years, significant progress has occurred in this rapidly advancing field, and much key research has been published. This book has gathered together pioneers in the field of epigenetics to produce thought-provoking discussions on classic aspects of epigenetics and on the newer emerging areas. It includes topics on the impact of metabolism on the epigenome, how our actions may impact the health of our offspring several generations removed, and how exposure to environmental toxicants can have l |
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