Methyl bromide risk characterization in California / / Subcommittee for the Review of the Risk Assessment of Methyl Bromide, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council

• Record Nr.: UNINA9910826471703321
• Pubbl/distr/stampa: Washington, D.C., : National Academy Press, 2000
• ISBN: 0-309-18368-5; 1-280-18544-9; 9786610185443; 0-309-56958-3; 0-585-32064-0
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (111 p.)
• Collana: Compass series
• Disciplina: 615.9/512
• Soggetti: Bromomethane - Toxicology - California; Health risk assessment - California
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "This project was supported by Agreement No. 98-0316 between the National Academy of Sciences and the California Department of Pesticide Regulation"--T.p. verso.
• Nota di bibliografia: Includes bibliographical references (p. 76-83).
• Nota di contenuto: METHYL BROMIDE RISK CHARACTERIZATION IN CALIFORNIA -- Copyright -- Preface -- Contents -- Executive Summary -- THE SUBCOMMITTEE'S TASK -- THE SUBCOMMITTEE'S EVALUATION -- Toxicology -- Recommendations -- Exposure -- Recommendations -- Risk Characterization -- Recommendations -- 1 Introduction -- BACKGROUND -- CALIFORNIA REGULATIONS -- THE SUBCOMMITTEE'S TASK -- ORGANIZATION OF THE REPORT -- 2 Toxicology and Hazard Identification -- PHARMACOKINETICS -- GENOTOXICITY -- ACUTE TOXICITY -- SUBCHRONIC TOXICITY -- CHRONIC INHALATION AND ONCOGENICITY -- REPRODUCTIVE TOXICITY -- DEVELOPMENTAL TOXICITY -- NEUROTOXICITY -- SELECTION OF CRITICAL EFFECTS FOR ACUTE TOXICITY -- 3 Exposure Assessment -- BACKGROUND -- LIKELY EXPOSURE SCENARIOS -- QUALITY OF DATA AVAILABLE FOR CHARACTERIZING EXPOSURES -- Analytical Methods -- ; Representativeness of Available Exposure Measurements -- Appropriateness of Normalizing Assumptions for Different Application Rates -- Appropriateness of Exposure-Duration Assumptions -- ACCURACY AND APPROPRIATENESS OF AVAILABLE MODELING TOOLS -- Exposure Estimates Based on Modeling -- Exposure of Residents in a Fumigated House -- Exposure of Residents Downwind from Soil Fumigations -- SUMMARY -- 4 Risk Characterization -- RISK CHARACTERIZATION GOALS -- HAZARD IDENTIFICATION -- Acute Toxicity Database -- Subchronic Toxicity Database -- Chronic Toxicity Database -- Developmental Neurotoxicity -- EXPOSURE ASSESSMENT -- Appropriateness of Acute-Exposure Definition -- Subchronic Exposure -- Chronic Exposure -- MARGIN-OF-EXPOSURE ANALYSIS -- Categories with More than Two Data Points -- Categories with One or Two Data Points -- UNCERTAINTY ISSUES -- Derivation of Reference Concentrations -- Sensitive Subpopulations -- Multiple Exposures -- SUMMARY -- 5 Conclusions and Recommendations -- TOXICOLOGICAL INFORMATION -- Conclusions -- Recommendations.; EXPOSURE ASSESSMENT -- Conclusions -- Recommendations -- RISK CHARACTERIZATION -- Conclusions -- Recommendations -- References -- Appendix A Biographical Information on the Subcommittee for the Review of the Risk Assessment of Methyl Bromide -- Appendix B Public Access Materials -- Appendix C Calculation of Air Exchange Rates -- ILLUSTRATIVE LOGNORMAL TREATMENT OF DATA FOR SELECTED OCCUPATIONAL EXPOSURES.