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Record Nr. |
UNINA9910826437803321 |
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Titolo |
Tumor microenvironment [[electronic resource] /] / edited by Dietmar W. Siemann |
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Pubbl/distr/stampa |
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Hoboken, : Wiley-Blackwell, 2011 |
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ISBN |
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1-282-82246-2 |
9786612822469 |
0-470-66989-6 |
0-470-66980-2 |
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Edizione |
[2nd ed.] |
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Descrizione fisica |
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1 online resource (464 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Cancer cells |
Carcinogenesis |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Tumor Microenvironment; Contents; Preface; List of Contributors; 1 The Microenvironment in Cancer; 2 Establishing the Tumor Microenvironment; 3 Contributions of the Extracellular Matrix to Tumorigenesis; 4 Matrix Metalloproteinases and Their Inhibitors - Friend or Foe; 5 Role of Tumor-Associated Macrophages (TAM) in Cancer Related Inflammation; 6 Bone Marrow Stroma and the Leukemic Microenvironment; 7 Microenvironment Factors Influencing Skeletal Metastases; 8 Premetastatic Niches; 9 Hypoxia, Anerobic Metabolism, and Interstitial Hypertension; 10 Hypoxia and the DNA Damage Response |
11 Non-Invasive Imaging of the Tumor Microenvironment12 Hypoxia-Inducible Factor 1 (HIF1) Mediated Adaptive Responses in the Solid Tumor; 13 Regulation of the Unfolded Protein Response in Cancer; 14 Influence of Hypoxia on Metastatic Spread; 15 Drug Penetration and Therapeutic Resistance; 16 Impact on Radiotherapy; 17 HIF-1 Inhibitors for Cancer Therapy; 18 Vascular-Targeted Molecular Therapy; Index |
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Sommario/riassunto |
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The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. |
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