Genome instability and transgenerational effects [[electronic resource] /] / Igor Kovalchuk and Olga Kovalchuk, editors

• Record Nr.: UNINA9910825076903321
• Pubbl/distr/stampa: New York, : Nova Science Publishers, c2010
• ISBN: 1-61761-663-X
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (490 p.)
• Collana: Genetics--research and issues series
• Altri autori (Persone): KovalchukIgor; KovalchukOlga, MD.
• Disciplina: 572.8/77
• Soggetti: Epigenesis; Mutation (Biology); Variation (Biology)
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: ""GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS""; ""GENOME INSTABILITY AND TRANSGENERATIONAL EFFECTS""; ""CONTENTS ""; ""PREFACE ""; ""GENETIC AND EPIGENETIC REGULATION OF TRANSGENERATIONAL CHANGES IN GENOME STABILITY: AN OVERVIEW""; ""REFERENCES ""; ""GENETIC AND EPIGENETIC MECHANISMS ENSURING STABILITY OF MAMMALIAN GENOMES""; ""ABSTRACT ""; ""INTRODUCTION ""; ""GENETIC MECHANISMS OF GENOME STABILITY ""; ""Direct Reversal of Damage ""; ""Base Excision Repair ""; ""Nucleotide Excision Repair ""; ""Mismatch Repair ""; ""Repair of DNA Strand Breaks by Homologous Recombination ""; ""Non-Homologous End Joining """"Cell Cycle Checkpoints ""; ""EPIGENETIC REGULATION OF GENOMIC STABILITY ""; ""DNA Methylation ""; ""Histone Modifications ""; ""Short RNA-Mediated Silencing ""; ""CONCLUSION ""; ""REFERENCES ""; ""GENETIC AND EPIGENETIC REGULATION OF GENOME STABILITY IN PLANTS""; ""ABSTRACT ""; ""INTRODUCTION ""; ""1. ENDOGENOUS AND EXOGENOUS FACTORS THAT AFFECT GENOME STABILITY""; ""1.1. Reactive Oxygen Species Challenge DNA the Repair Machinery and Decrease Genome Stability ""; ""1.2. The Choice of DNA Repair Pathway May Regulate Plant Genome Stability ""; ""1.3. The Importance of Plant Genome Plasticity for Stress Tolerance ; and Genome Evolution""""2. MECHANISMS AND FUNCTIONS OF EPIGENETIC REGULATIONS IN THE PLANT GENOME ""; ""2.1. DNA Methylation Is a Critical Component in the System of Epigenetic Modifications in Plants""; ""2.2. Histone Modifications and DNA Methylation Are Interdependent ""; ""2.3. Chromatin Remodeling Shapes Chromatin Structure and Complements DNA and Histone Modifications""; ""3. EPIGENETIC MODIFICATIONS â€? A STRESS-RESPONSIVE MECHANISM CONTROLLING GENE REGULATION AND GENOME STABILITY""; ""3.1. Effects of Stress on Epigenetic Regulations """"3.2. Small RNAs May Direct Epigenetic Modifications to a Specific Genomic Locus""; ""3.2.1. The Complexity and Functional Redundancy of smRNA Biogenesis Pathways in Arabidopsis ""; ""3.2.2. Mechanisms of smRNA-Directed Epigenetic Regulations ""; ""3.2.3. Small RNA Biogenesis is a Sensitive Stress-Responsive System ""; ""4. INDUCIBLE EPIGENETIC CHANGES MAY CHANGE GENOME STABILITY AND GUIDE GENOME EVOLUTION""; ""CONCLUDING REMARKS ""; ""ACKNOWLEDGMENTS ""; ""REFERENCES ""; ""EVOLUTION OF THE FPG/NEI FAMILY OF DNA GLYCOSYLASES ""; ""ABSTRACT """"ABBREVIATIONS ""; ""INTRODUCTION ""; ""METHODS ""; ""EVENTS IN THE FPG/NEI PHYLOGENY ""; ""Horizontal Transfer ""; ""Changes in Substrate Specificity ""; ""Changes in the Structural Zinc-Finger Motif ""; ""Expansion within the Actinobacteria ""; ""THE ENZYMATIC FUNCTION OF THE FPG2 GLADE REMAINS UNKNOWN ""; ""CONCLUSION ""; ""REFERENCES ""; ""STRESS-INDUCED MUTAGENESIS IN BACTERIA ""; ""ABSTRACT ""; ""INTRODUCTION ""; ""STRESSFUL (MUTAGENIC) FACTORS ""; ""STRESS RESPONSE TO ENDOGENOUS AND EXOGENOUS DNA-DAMAGING AGENTS""; ""TRANSLESION DNA SYNTHESIS ""; ""THE GENERAL STRESS RESPONSE ""