1.

Record Nr.

UNINA9910825073903321

Titolo

Huntington's disease / / edited by Gillian Bates, Sarah Tabrizi and Lesley Jones ; Véronique M. André [and thirty seven others], contributors

Pubbl/distr/stampa

New York : , : Oxford University Press, , 2014

©2014

ISBN

0-19-937047-8

0-19-937048-6

0-19-992915-7

Edizione

[Fourth edition.]

Descrizione fisica

1 online resource (513 p.)

Collana

Oxford Monographs on Medical Genetics

Disciplina

616.85/1

Soggetti

Huntington's chorea

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references at the end of each chapters and index.

Nota di contenuto

""Cover""; ""Huntington�s Disease""; ""Series""; ""Copyright""; ""Contents""; ""Contributors""; ""Section one Clinical Aspects of Huntington�s Disease""; ""1 Huntington�s Disease in a Historical Context""; ""2 Clinical Neurology""; ""3 Neuropsychiatry and Neuropsychology""; ""4 Juvenile Huntington�s Disease""; ""5 Premanifest and Early Huntington�s Disease""; ""Section two Genetics of Huntington�s Disease""; ""6 Genetic and Molecular Studies""; ""7 Epidemiology""; ""8 Genetic Counseling and Testing""; ""Section three Neurobiology of Huntington�s Disease""

""9 Neuropathology in the Human Brain""""10 Altered Neuronal Circuitry""; ""Section Four Molecular Biology of Huntington�s Disease""; ""11 Normal Function of Huntingtin""; ""12 Structural Biology: Order, Disorder, and Conformational Flux""; ""13 Pathogenic Mechanisms""; ""14 Peripheral Pathology""; ""Section five Therapeutic Interventions in Huntington�s Disease""; ""15 Comprehensive Care""; ""16 Preclinical Experimental Therapeutics""; ""17 Experimental Therapeutics: Moving Forward in Clinical Trials""; ""Index""

Sommario/riassunto

This fourth edition of Huntington's Disease presents a comprehensive summary of the current knowledge of this disease, including the major



scientific and clinical advances that have occurred since publication of the third edition in 2002. Completely updated and expanded, chapters in this volume are organized in five sections: DT Clinical aspects of Huntington's disease, including updated chapters on historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and new chapters on juvenile Huntington's and the premanifest and early stages DT The genetics of Huntington