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1. |
Record Nr. |
UNINA9910465172503321 |
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Autore |
Vijg Jan |
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Titolo |
Aging of the genome [[electronic resource] ] : the dual role of DNA in life and death / / Jan Vijg |
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Pubbl/distr/stampa |
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Oxford, : Oxford University Press, 2007 |
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ISBN |
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9786611145255 |
1-281-14525-4 |
0-19-856922-X |
0-19-152458-1 |
1-4294-6993-5 |
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Descrizione fisica |
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1 online resource (385 p.) |
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Disciplina |
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Soggetti |
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Aging - Genetic aspects |
Genomes |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Contents; Preface; 1 Introduction: the coming of age of the genome; 1.1 The age of biology; 1.2 From genetics to genomics; 1.3 A return to function; 1.4 The causes of aging: a random affair; 2 The logic of aging; 2.1 Aging genes; 2.2 Pleiotropy in aging; 2.3 Interrupting the pathways of aging; 2.4 Longevity-assurance genes; 2.5 Somatic damage and the aging genome; 3 Genome structure and function; 3.1 DNA primary structure; 3.2 Higher-order DNA structure; 3.3 Nuclear architecture; 3.4 Transcription regulation; 3.5 Conclusions; 4 Genome maintenance; 4.1 Why genome maintenance? |
4.2 DNA-damage signaling and cellular responses4.3 DNA-repair mechanisms; 4.4 Genome maintenance and aging; 5 Genome instability and accerated aging; 5.1 Premature aging; 5.2 Validity of accelerated-aging phenotypes; 5.3 Genome maintenance and accelerated aging in mice; 5.4 Conclusions; 6 The aging genome; 6.1 DNA damage; 6.2 DNA-sequence changes; 6.3 Changes in DNA modification and conformation; 6.4 Summary and conclusions: a DNA damage report of aging; 7 From genome to phenome; 7.1 The causes of cancer; 7.2 |
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Genome instability and tissue dysfunction |
7.3 Testing the role of genome instability in aging8 A genomic limit to life?; 8.1 Aiming for immortality; 8.2 SENS, and does it make sense?; EPILOGUE; GLOSSARY; A; B; C; D; E; F; G; H; I; L; M; N; O; P; R; S; T; X; Y; Z; REFERENCES; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
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Sommario/riassunto |
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Aging has long been ascribed to the gradual accumulation of mutations in the genome. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. This book reviews the concept of genomic instability as a possible universal cause of aging in complex organisms resulting from recent advances in functional genomics and systems biology. - ;Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technol |
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2. |
Record Nr. |
UNINA9910817951903321 |
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Autore |
Mills Philip |
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Titolo |
The ancient Mediterranean trade in ceramic building materials : a case study in Carthage and Beirut / / Philip Mills |
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Pubbl/distr/stampa |
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Oxford : , : Archaeopress, , [2013] |
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©2013 |
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ISBN |
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Descrizione fisica |
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1 online resource (x, 132 pages) : illustrations, maps |
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Collana |
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Roman and late antique Mediterranean pottery ; ; 2 |
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Disciplina |
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Soggetti |
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Pottery, Roman - Mediterranean Region |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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3. |
Record Nr. |
UNINA9910824851803321 |
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Autore |
Condon Bradly J. |
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Titolo |
Drawing lines in sand and snow : border security and North American economic integration / / Bradly J. Condon and Tapen Sinha |
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Pubbl/distr/stampa |
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London, [England] ; ; New York, New York : , : Routledge, , 2015 |
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©2003 |
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ISBN |
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1-315-29020-0 |
1-315-29021-9 |
1-315-29019-7 |
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Descrizione fisica |
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1 online resource (239 pages) : illustrations, tables |
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Disciplina |
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Soggetti |
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Free trade - North America |
Border security - North America |
Border security - United States |
Noncitizens - United States |
Border patrols - United States |
Capital movements - North America |
Illegal immigration |
North America Economic integration |
North America Foreign economic relations |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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First published 2003 by M.E. Sharpe. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Bordering on the USA: The Political Economy of North American Integration -- Get Me to the Plant on Time: Delivering the Goods in an Integrated Economy -- Do You Know the Way to San Jose? Integrating Labor Markets and Securing Borders -- Doing the Laundry: Cross-Border Capital Movements -- Invisible Elephants: Corruption and Cooperation -- Three's Company: NAFTA as a Bloc |
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Sommario/riassunto |
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This important book addresses the major issues facing the North American continent: security, economic integration, border management, corruption, and undocumented migration.-adapted from Ebook Central description |
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