Cancer vaccines and tumor immunity / / [edited by] Rimas Orentas, James W. Hodge, Bryon D. Johnson

• Record Nr.: UNINA9910824723903321
• Pubbl/distr/stampa: Hoboken, N.J., : Wiley-Interscience, c2008
• ISBN: 1-281-23718-3; 9786611237189; 0-470-17011-5; 0-470-17010-7
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (352 p.)
• Altri autori (Persone): OrentasRimas; HodgeJames W; JohnsonBryon D
• Disciplina: 616.99/407
• Soggetti: Cancer vaccines; Tumors - Immunological aspects
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: CANCER VACCINES AND TUMOR IMMUNITY; CONTENTS; Contributors; Foreword CANCER VACCINES AND CANCER IMMUNOTHERAPY: A NEW PARADIGM; I INTRODUCTION; 1 CANCER VACCINES: PROGRESS AND PROMISE; II ADJUVANT THERAPY: ENHANCING THE ENDOGENOUS IMMUNE RESPONSE; 2 FULLY SYNTHETIC CARBOYHYDRATE-BASED ANTITUMOR VACCINES; 3 BACILLUS CALMETTE-GUÉRIN IMMUNOTHERAPY OF GENITOURINARY CANCER; 4 STIMULATION OF TOLL-LIKE RECEPTOR 9 FOR ENHANCING VACCINATION; III ANTIGEN-SPECIFIC THERAPY: NOVEL PRESENTATION OF PEPTIDE AND PROTEIN ANTIGENS; 5 POLYEPITOPE VACCINES; 6 ANTIGEN-SPECIFIC CANCER IMMUNOTHERAPY: HPV-ASSOCIATED CERVICAL CANCER AS A MODEL SYSTEM7 POXVIRAL VECTORS FOR CANCER VACCINES: STATE OF THE ART; 8 IMMUNOTHERAPEUTIC STRATEGIES AGAINST CANCER USING Listeria monocytogenes AS A VECTOR FOR TUMOR ANTIGENS; 9 COUPLING INNATE AND ADAPTIVE IMMUNITY WITH YEAST-BASED CANCER IMMUNOTHERAPY; IV CELL-BASED THERAPY: USING CANCER CELLS AS A MEANS TO INDUCE ; SPECIFIC TUMOR IMMUNITY; 10 ALLOGENEIC WHOLE-CELL VACCINES; 11 JUMP-STARTING TUMOR IMMUNITY WITH BREAST CANCER THERAPEUTICS; 12 T-REGULATORY CELL MANIPULATION IN TUMOR IMMUNOTHERAPY; 13 TUMOR VACCINATION AFTER AUTOLOGOUS HSCT: WHAT HAS BEEN LEARNED FROM EXPERIMENTAL MODELS14 VACCINES IN THE SETTING OF HEMATOPOIETIC STEM CELL TRANSPLANTATION; 15 INTRATUMOR GENERATION OF VIGOROUS ANTITUMOR IMMUNE RESPONSES; 16 CANCER IMMUNOTHERAPY: UNTAPPING THE POTENTIAL OF COSTIMULATORY MOLECULES BEYOND CTLA-4; V DEFINING EFFECTIVE CLINICAL RESPONSES; 17 ADVANCES IN IMMUNE MONITORING STRATEGIES FOR CANCER VACCINES AND IMMUNOTHERAPY; 18 IMMUNE EVALUATION OF CANCER VACCINES; Index
• Sommario/riassunto: Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.