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1. |
Record Nr. |
UNINA990001110820403321 |
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Autore |
Velo, Giorgio |
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Titolo |
Rigorous Atomic and Molecular Physics : Proceedings of the Fourth International School of Mathematical Physics held 1-15, 1980 in Erice, Sicily, Italy / edited by G. Velo and A.S. Wightman |
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Pubbl/distr/stampa |
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New York [etc.] : Plenum Press, 1981 |
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ISBN |
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Collana |
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NATO ASI series . Series B , Physics ; 74 |
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Disciplina |
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Locazione |
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Collocazione |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Published in cooperation with NATO Scientific Affairs Division. |
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2. |
Record Nr. |
UNINA9910691624103321 |
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Autore |
Lane R. C (Ronald C.), <1946-> |
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Titolo |
Hydrogeologic and water-quality reconnaissance of the artesian aquifer under the Shoalwater Bay Indian Reservation and Tokeland Peninsula, Pacific County, Washington, 1998-99 [[electronic resource] /] / by R.C. Lane and J.C. Ebbert ; prepared in cooperation with the Shoalwater Bay Indian Tribe |
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Pubbl/distr/stampa |
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Tacoma, Wash. : , : U.S. Dept. of the Interior, U.S. Geological Survey, , 2002 |
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Collana |
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Water-resources investigations report ; ; 01-4023 |
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Altri autori (Persone) |
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Soggetti |
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Groundwater - Washington (State) - Shoalwater Bay Indian Reservation |
Hydrogeology - Washington (State) - Shoalwater Bay Indian Reservation |
Water quality - Washington (State) - Shoalwater Bay Indian Reservation |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di bibliografia |
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Includes bibliographical references. |
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3. |
Record Nr. |
UNINA9910824244503321 |
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Autore |
Bain Lisa J. |
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Titolo |
Therapeutic development in the absence of predictive animal models of nervous system disorders : proceedings of a workshop / / Lisa Bain [and three others], rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Health and Medicine Division, the National Academies of Sciences, Engineering, Medicine |
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Pubbl/distr/stampa |
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Washington, District of Columbia : , : National Academies Press, , 2017 |
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©2017 |
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ISBN |
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Descrizione fisica |
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1 online resource (95 pages) : illustrations |
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Disciplina |
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Soggetti |
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Nervous system - Diseases |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Introduction and overview -- Drug development for nervous system disorders: overview of challenges and potential opportunities -- Case studies: therapeutic development for Parkinson's disease and schizophrenia in the absence of predictive animal models of disease -- New modeling approaches for nervous system disorders -- Private-sector thresholds for investment in neuroscience clinical trials -- Ethical considerations -- Regulatory perspectives -- Appendix A: References -- Appendix B: Workshop agenda -- Appendix C: Registered attendees. |
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Sommario/riassunto |
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"Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the pharmaceutical industry. This retreat by industry has been fueled by the high failure rate of compounds in advanced clinical trials for nervous system disorders. In response to the de-emphasis of CNS disorders in therapeutic development relative to other disease areas such as cancer, |
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metabolism, and autoimmunity, the National Academies of Sciences, Engineering, and Medicine initiated a series of workshops in 2012 to address the challenges that have slowed drug development for nervous system disorders. Motivated by the notion that advances in genetics and other new technologies are beginning to bring forth new molecular targets and identify new biomarkers, the Academies hosted the third workshop in this series in September 2016. Participants discussed opportunities to accelerate early stages of drug development for nervous system disorders in the absence of animal models that reflect disease and predict efficacy. This publication summarizes the presentations and discussions from the workshop"-- |
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