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Record Nr. |
UNINA9910155685803321 |
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Autore |
Parker Samuel |
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Titolo |
Purgatory Road |
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Pubbl/distr/stampa |
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ISBN |
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Formato |
Musica |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Named one of Library Journal's Best Books of 2017"Exceptional first novel."--Publishers Weekly, starred review"Will grip suspense aficionados from the first page."--Library Journal, starred review"A skillfully written, gripping thriller."--Booklist"Action-packed with breakneck pacing."--Foreword ReviewsWhen a day trip out of Las Vegas with his wife takes a turn for the worse, Jack is sure that he has the ability to get them home. But he drove into something far beyond reason.Rescue comes in the form of a desert hermit, but hope fades as the couple comes to realize that the nomad has no intention of letting them leave. A chance encounter with a kidnapped runaway and her crazed abductor leads them all farther into the wilderness--and closer to the cold brutality that isolation brings.At the edge of his sanity, Jack begins to learn that playing by another's rules may be the only way to survive.In a voice that is as hypnotizing as a desert mirage, debut novelist Samuel Parker entices readers down a dangerous road, where the forces of good and evil are as crushing as the Mojave heat. This is suspense in its purest, most unfiltered form. |
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2. |
Record Nr. |
UNINA9910809059703321 |
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Autore |
Schmiedel Jörn Matthias <1985-> |
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Titolo |
The role of microRNAs in controlling protein expression noise / / von Diplom Biophysiker Jörn Matthias Schmiedel |
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Pubbl/distr/stampa |
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Berlin : , : Logos Verlag Berlin, , [2016] |
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©2016 |
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ISBN |
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Descrizione fisica |
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1 online resource (116 pages) : illustrations |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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PublicationDate: 20160331 |
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Nota di bibliografia |
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Includes bibliographical references (pages 103-114). |
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Sommario/riassunto |
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Long description: The expression of genes is based on stochastic processes, which lead to temporal fluctuations in the number of proteins of each gene. If such fluctuations become too large they can be detrimental to the fitness of an organisms, because most cellular processes are based on the precise interaction of proteins. This PhD thesis explores the role of post-transcriptional regulatory mechanisms in the control of stochasticity in gene expression, with a focus on microRNAs, common regulators in multicellular organisms. Bioinformatic data analysis, mathematical modeling and single cell expression experiments are used to analyze the conditions under which microRNAs can lead to the reduction of fluctuations in gene expression. The central insight of this thesis is that microRNAs can indeed reduce fluctuations for most genes and that they are likely used by organisms for this purpose, thus ensuring precision to gene expression during development and the maintenance of the adult body. Der Expression von Genen liegen stochastische Prozesse zu Grunde, die zu Fluktuationen in der Menge von Proteinen eines jeden Gens führen. Zu starke Fluktuationen in Proteinmengen können für Organismen schädlich sein, da die meisten zellulären Prozesse auf der präzisen Wechselwirkung von Proteinen beruhen. Diese Dissertationsschrift |
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befasst sich mit dem Einfluss von post-transkriptionellen Regulationsmechanismen auf die stochastischen Prozesse der Genexpression. Mittels bioinformatischer Datenanalyse, mathematischer Modellierung und gezielten Einzelzellexperimenten wird mit Fokus auf die in Mehrzellern weitverbreiteten microRNAs erforscht unter welchen Voraussetzungen Organismen post-transkriptionelle Regulation zu Verringerung von Fluktuationen benutzen können. Die zentrale Erkenntnis der vorliegenden Arbeit ist, dass microRNAs für die meisten Gene Fluktuationen verringern können und auch zu diesem Zweck genutzt werden. |
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3. |
Record Nr. |
UNINA9910823931703321 |
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Titolo |
The transhumanist reader : classical and contemporary essays on the science, technology, and philosophy of the human future / / edited by Max More and Natasha Vita-More |
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Pubbl/distr/stampa |
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Chichester, West Sussex, U.K., : Wiley-Blackwell, 2013 |
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ISBN |
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9781118329399 |
1118329392 |
9781118555927 |
1118555929 |
9781118555996 |
1118555996 |
9781299277588 |
1299277586 |
9781118555965 |
1118555961 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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Altri autori (Persone) |
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MoreMax <1964-> |
Vita-MoreNatasha <1950-> |
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Disciplina |
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Soggetti |
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Medical technology - Social aspects |
Humanism - History |
Human body (Philosophy) - History |
Genetic engineering - Social aspects |
Tecnologia mèdica |
Condicions socials |
Humanisme |
Enginyeria genètica |
Llibres electrònics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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pt. I. Roots and core themes -- pt. II. Human enhancement : the somatic sphere -- pt. III. Human enhancement : the cognitive sphere -- pt. IV. Core technologies -- pt. V. Engines of life : identity and beyond death -- pt. VI. Enhanced decision-making -- pt. VII. Biopolitics and policy -- pt. VIII. Future trajectories : singularity -- pt. IX. The world's most dangerous idea. |
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Sommario/riassunto |
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The first authoritative and comprehensive survey of the origins and current state of transhumanist thinking The rapid pace of emerging technologies is playing an increasingly important role in overcoming fundamental human limitations. Featuring core writings by seminal thinkers in the speculative possibilities of the posthuman condition, essays address key philosophical arguments for and against human enhancement, explore the inevitability of life extension, and consider possible solutions to the growing issues of social and ethical implications and concerns. Edited by the international |
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