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Record Nr. |
UNINA9910455447303321 |
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Titolo |
Pharmacokinetics in risk assessment [[electronic resource] /] / Subcommittee on Disinfectants and Disinfectant By-Products, Safe Drinking Water Committee, Board on Toxicology and Environmental Health Hazards, Assembly of Life Sciences, National Research Council |
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Pubbl/distr/stampa |
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Washington, D.C., : National Academy Press, 1987 |
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ISBN |
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1-280-22160-7 |
9786610221608 |
0-309-55769-0 |
0-585-15539-9 |
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Descrizione fisica |
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1 online resource (512 p.) |
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Collana |
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Drinking water and health ; ; v.8 |
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Disciplina |
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Soggetti |
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Drinking water - Contamination - United States |
Drinking water - Contamination |
Drinking water - Health aspects - United States |
Drinking water - Health aspects |
Water - Pollution - Toxicology |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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""Pharmacokinetics in Risk Assessment""; ""Copyright""; ""PREFACE""; ""Contents""; ""PART I INTRODUCTION: THE PROBLEM AND AN APPROACH ""; ""Risk Assessment: Historical Perspectives""; ""References""; ""Tissue Dosimetry in Risk Assessment, or What's the Problem Here Anyway?""; ""INTRODUCTION""; ""A DOSE OF WHAT?""; ""ISN'T THIS VOLUME ABOUT PHARMACOKINETICS?""; ""GENOTOXIC CARCINOGENS""; ""PARENT CHEMICAL""; ""STABLE METABOLITES""; ""REACTIVE, NONISOLATABLE METABOLITES""; ""INTERCALATING AGENTS""; ""EPIGENETIC CARCINOGENS""; ""SUMMARY""; ""References""; ""PART II MATHEMATICAL MODELING "" |
""Modeling: An Introduction""""References""; ""Physiologically Based Pharmacokinetic Modeling""; ""INTRODUCTION""; ""BIOLOGICAL BASIS OF PHYSIOLOGICAL PHARMACOKINETICS""; ""DEVELOPMENT OF |
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MODELS""; ""CHOICE OF COMPARTMENTS""; ""BASIC MASS BALANCES""; ""Mass Balance: Blood Pool""; ""Mass Balance: Tissue Region i""; ""SIMPLIFICATIONS OF MASS BALANCES""; ""Examples""; ""DISCUSSION""; ""FUTURE RESEARCH NEEDS""; ""References""; ""PART III GENERALIZATIONS AND EXTRAPOLATIONS ""; ""Allometry: Body Size Constraints in Animal Design""; ""INTRODUCTION""; ""SIZE, DESIGN, AND PHARMACOKINETICS"" |
""Aerobic Energetics of Muscle In Vivo""""Conflict of Physiological and Chronological Time""; ""Species Extrapolations, Physiological Time, and Pharmacokinetics""; ""CONCLUSIONS""; ""SUMMARY""; ""References""; ""Prediction of In Vivo Parameters of Drug Metabolism and Distribution from In Vitro Studies""; ""IN VITRO PREDICTION OF IN VIVO DRUG METABOLISM""; ""IN VITRO PREDICTION OF IN VIVO DRUG BINDING AND DISTRIBUTION""; ""CONCLUSION""; ""References""; ""Dose, Species, and Route Extrapolation: General Aspects""; ""DIFFERENT PROBLEMS AND OBJECTIVES, DIFFERENT MODELS""; ""Different Mechanisms"" |
""GENERAL PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS""""Simplification of Models""; ""Rates of Formation of Complexes""; ""Diffusional Barriers and Modified Fick's Law""; ""Simple PB-PK Models""; ""Basic Parameters fu and R""; ""Nonlinear Kinetics and Lost Concepts""; ""INTERFACE BETWEEN PB-PK MODELS AND CLEARANCES""; ""Organ Availabilities (F), Extraction Ratios (E), and Clearances (CL)""; ""Physiologically Based Linear Compartmental Pharmacokinetic Models""; ""Validity of the Assumption of Virtual Steady State""; ""Calculation of Other Compartmental Model Parameters"" |
""Approximations of Terminal Half-Lives""""Approximate Time Required to Approach Steady State""; ""LINEAR PHARMACOKINETIC SYSTEMS""; ""Total Body Clearance""; ""Importance of the Unbound Concentration of Substances""; ""Classification of Organs; Routes of Administration""; ""Non-First-Pass, Nonelimination Organs""; ""Range of Maximum and Minimum Unbound Concentrations in Nonelimination Organs and Repetitive Administration""; ""Non-First-Pass, Elimination Organs""; ""FIRST-PASS, NONELIMINATION ORGANS""; ""First-Pass, Elimination Organs""; ""ROUTE-TO-ROUTE EXTRAPOLATION"" |
""Lungs and Skin Administration"" |
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2. |
Record Nr. |
UNINA9910823924303321 |
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Autore |
Johann Susan |
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Titolo |
Focus on playwrights : portraits and Interviews / / Susan Johann |
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Pubbl/distr/stampa |
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[South Carolina] : , : The University of South Carolina Press, , [2016] |
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©2016 |
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ISBN |
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Descrizione fisica |
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1 online resource (185 p.) |
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Disciplina |
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Soggetti |
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Dramatists, American - 20th century |
Dramatists, American - 21st century |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Interviews/Text: Prologue -- Deceptive simplicity: an introduction / by Alexandra C. Anderson -- What we were, what we are: a dialogue with Marsha Norman and Christopher Durang -- August Wilson -- George Abbott -- Romulus Linney -- Nicky Silver -- Wendy Wasserstein -- A.R. Gurney -- Robert Patrick -- Marsha Norman -- Craig Lucas -- Christopher Durang -- Sidney Kingsley -- Sarah Ruhl -- Arthur Miller -- Garson Kanin -- Christopher Shinn -- Edward Albee -- Acknowledgments -- Index of playwrights -- About the author -- Photographs: Edward Albee -- Bill Irwin -- Beth Henley -- John Schenkar -- Ed Bullins -- Seven playwrights -- Spalding Gray -- William Finn -- August Wilson -- Steven Drukman -- George C. Wolfe -- Polly Pen -- Eduardo Machado -- Sybille Pearson -- Tom Stoppard -- Adam Rapp -- John Ford Noonan -- George Abbott -- Abbott's country desk -- Romulus Linney -- Nicky Silver -- Jeffrey Hatcher -- John Patrick Shanley -- Suzan-Lori Parks -- Adrienne Kennedy -- Reinaldo Povod -- Sam Shepard -- Keith Glover -- Wendy Wasserstein -- A.R. Gurney -- Robert Patrick -- Carl Hancock Rux -- Naomi Wallace -- Michael Weller -- Maria Irene Fornes -- David Ives -- Al CArmines -- Neil LaBute -- Charles Mee -- Marsha Norman -- Conor McPherson -- Ariel Dorfman -- Horton Foote -- Keith Reddin -- Dael Orlandersmith -- Jim Grimsley -- Tina Howe -- Craig Lucas -- Everett Quinton -- Lynn Nottage -- David Henry Hwang -- Jean-Claude van |
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Itallie -- Paul Rudnick -- Richard Dresser -- Christopher Durang -- Marcus Gardley -- David Lindsay-Abaire -- Charlayne Woodard -- Charles Busch -- Anna Deavere Smith -- Nilo Cruz -- Lanford Wilson -- Arthur Kopit -- John Peilmeier -- Sidney Kingsley -- Jon Robin Baitz -- Thomas Babe -- Joan Ackermann -- Eve Ensler -- Ping Chong -- Jules Feiffer -- Donald Margulies -- Terrence McNally -- Sarah Ruhl -- Richard Foreman -- Joe Chaikin -- John Guare -- Young Jean Lee -- Lee Blessing -- Tony Kushner -- Arthur Miller -- Garson Kanin -- David Greenspan -- Jonathan Harvey -- OyamO -- Paula Vogel -- Eric Bogosian -- Christopher Shinn -- David Drake -- Kim Merrill -- Lisa Kron -- David Hare. |
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Sommario/riassunto |
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In 1989 Susan Johann was hired to photograph Christopher Durang for a magazine article about his play Naomi in Her Living Room. The playwright was known for his outrageous comedy, so Johann anticipated a session with a rather wild, young eccentric. To her surprise, the man who came to her studio was mild mannered and buttoned down. Johann found this twist captivating, and it was then that this project was born. Over the ensuing twenty-year period, she photographed more than ninety playwrights, including many winners of the Pulitzer Prize and other prestigious awards. Johann photographed Wendy Wasserstein, Anna Deavere Smith, August Wilson, and Nilo Cruz in the weeks after they won the Pulitzer. Tony Kushner sat for his portrait between the productions of part 1 and part 2 of Angels in America. Eve Ensler came to Johann's studio during the week she was previewing her famous one-woman show, The Vagina Monologues, and George C. Wolfe sat for her the morning after his play Spunk opened at the Public Theater. Each playwright was photographed in Johann's studio using the same film, a single light, and a plain backdrop, creating a portrait that captures and distills something essential--an intimate view. Her interviews explore the writers' personal and creative journeys including their inspirations, roadblocks, and obsessions, which influenced their work on paper and on the stage. Even those who know Edward Albee's plays intimately, for example, may be surprised by his incisive wit and inimitable voice as revealed in his interview with Johann. Beyond the book, Focus on Playwrights is also a live, multimedia presentation in which Johann narrates an inside look at creativity--the theater and photography. It has been given at such venues as the New Dramatists in New York, the Eugene O'Neill Theater, the Tryon Fine Arts Center and at the Photo Expo in New York. |
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3. |
Record Nr. |
UNINA9910971248903321 |
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Autore |
Ohl Vicki <1950-> |
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Titolo |
Fine & dandy : the life and work of Kay Swift / / Vicki Ohl |
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Pubbl/distr/stampa |
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New Haven, : Yale University Press, c2004 |
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ISBN |
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1-281-73059-9 |
9786611730598 |
0-300-13039-2 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (329 p.) |
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Disciplina |
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Soggetti |
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Composers - United States |
Women composers - United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes list of works (p. 243-250), bibliographical references (p. 279-284), and index. |
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Nota di contenuto |
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Prelude -- Professional and personal choices -- Highbrow/lowbrow in New York City -- Fine and dandy -- Stagestruck : the ballet to Radio City -- Gershwin obsession -- New frontiers -- She'll have Manhattan -- Challenges -- The show won't fold in Philadelphia -- Keep on keepin' on -- Finale. |
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Sommario/riassunto |
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Kay Swift (1897-1993) was one of the few women composers active on Broadway in the first half of the twentieth century. Best known as George Gershwin's assistant, musical adviser, and intimate friend, Swift was in fact an accomplished musician herself, a pianist and composer whose Fine and Dandy (1930) was the first complete Broadway musical written by a woman. This fascinating book-the first biography of Swift-discusses her music and her extraordinary life.Vicki Ohl describes Swift's work for musical theater, the ballet, Radio City Music Hall's Rockettes, and commercial shows. She also tells how Swift served as director of light music for the 1939 World's Fair, eloped with a cowboy from the rodeo at the fair, and abandoned her native New York for Oregon, later fashioning her experiences into an autobiographical novel, Who Could Ask for Anything More? Informed by rich material, including Swift's unpublished memoirs and extensive interviews with |
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her family members and friends, this book captures the essence and spirit of a remarkable woman. |
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