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Record Nr. |
UNINA9910298640103321 |
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Autore |
Wang Fangjun |
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Titolo |
Applications of monolithic column and isotope dimethylation labeling in shotgun proteome analysis / / Fangjun Wang |
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Pubbl/distr/stampa |
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Heidelberg, Germany : , : Springer, , 2014 |
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ISBN |
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Edizione |
[1st ed. 2014.] |
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Descrizione fisica |
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1 online resource (xiii, 94 pages) : illustrations (some color) |
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Collana |
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Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5053 |
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Disciplina |
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Soggetti |
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Proteins - Analysis |
Proteomics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Introduction -- Online sample injection and multidimensional chromatography separation by using strong cation exchange monolithic column -- Development of polymer-based hydrophobic monolithic columns and their applications in proteome analysis -- Large-scale proteome and phosphoproteome quantification by using dimethylation isotope labeling. |
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Sommario/riassunto |
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In this thesis, the author outlines the development of new monolithic columns and isotope dimethyl labeling strategies and their applications in high-performance proteome analyses. Though different types of monolithic columns have been widely developed for chromatography and electrophoresis separation, their application in proteomics for complex peptide mixtures separation is still a challenge. The author discusses the preparation of new monolithic columns and optimization of chromatography separation capability to improve coverage and accuracy of proteome analysis. Further, the author describes a novel online multidimensional chromatography system combined with automated online isotope labeling, which significantly improves the throughput, sensitivity, and accuracy of quantitative proteomics. In addition to the development of new technologies, the author investigates the proteome and phosphoproteome expression changes of clinical hepatocellular carcinoma tissues and the hippocampi of mice with Alzheimer’s disease. The work in this thesis has led to several |
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publications in high-profile journals in the fields of analytical chemistry and proteome research. |
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2. |
Record Nr. |
UNINA9910823361203321 |
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Autore |
Scruton Roger |
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Titolo |
The West and the rest : globalization and the terrorist threat / / Roger Scruton |
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Pubbl/distr/stampa |
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London, England ; ; New York, New York : , : Continuum, , 2002 |
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©2002 |
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ISBN |
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1-282-71060-5 |
9786612710605 |
1-4411-9289-1 |
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Descrizione fisica |
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1 online resource (200 p.) |
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Disciplina |
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Soggetti |
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Globalization |
Terrorism |
Religion and international relations |
Globalization - Religious aspects - Islam |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents; Preface; 1. The Social Contract; 2. Enlightenment, Citizenship, and Loyalty; 3. Holy Law; 4. Globalization; 5. Conclusion; Notes; Index |
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Sommario/riassunto |
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In this astonishing new book, Roger Scruton argues that to understand adequately the roots of Islamic terrorism, one must understand both the unique historical evolution of the state and the dynamic of globalization.With extraordinary perception, Scruton |
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