| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910822860003321 |
|
|
Titolo |
Traffic safety / / edited by George Yannis, Simon Cohen |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
London, England ; ; Hoboken, New Jersey : , : ISTE Ltd : , : John Wiley and Sons Inc., , 2016 |
|
©2016 |
|
|
|
|
|
|
|
|
|
ISBN |
|
1-119-30784-8 |
1-119-30783-X |
1-119-30785-6 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (421 p.) |
|
|
|
|
|
|
Collana |
|
Science, Society and New Technologies Series. Research for Innovative Transports Set ; ; 4 |
THEi Wiley ebooks |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Traffic safety - Social aspects |
Traffic safety - Research |
Conference papers and proceedings. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Cover; Title Page; Copyright; Contents; Acknowledgments; Preface; Introduction; PART 1: Road Safety Policy; PART 2: Accident Analysis and Modeling; PART 3: Vulnerable Road Users' Safety; PART 4: Road Infrastructure Safety; PART 5: ITS and Safety; PART 6: Railway Safety; List of Authors; Index; EULA; Main findings; Conclusion; 1: Analysis of Road Safety Management Systems in Europe; 2: Conceptualizing Road Safety Management through a Territorialized Complex System: Context and Goals; 3: Development of the European Road Safety Knowledge System |
4: Structural Time Series Modeling of the Number of Fatalities in Poland in Relation to Economic Factors5: Risk of Road Traffic Injuries for Pedestrians, Cyclists, Car Occupants and Powered Two-Wheel Users, based on a Road Trauma Registry and Travel Surveys, Rhône, France; 6: Development of Safety Performance Functions for Two-Lane Rural First-Class Main Roads in Hungary; 7: Mobility and Safety of Powered Two-Wheelers in OECD Countries; 8: Comparison of Car Drivers' and |
|
|
|
|
|
|
|
|
|
|
Motorcyclists' Drink Driving in 19 Countries: Results from the SARTRE 4 Survey |
9: Trajectories of Multiple People in Crowds Using Laser Range Scanner10: Safety of Urban Cycling: A Study on Perceived and Actual Dangers; 11: Speed Distribution and Traffic Safety Measures; 12: Ex-ante Assessment of a Speed Limit Reducing Operation - A Data-driven Approach; 13: Development of a Guideline for the Selection of Vehicle Restraint Systems - Identification of the Key Selection Parameters; 14: For the Vision of "Zero Accidents at Intersections": A Challenge between Road Safety and Capacity; 15: Safety Inspection and Management of the Road Network in Operation |
16: Improving Safety and Mobility of Vulnerable Road Users Through ITS Applications17: Experimentation with the PRESERVE VSS and the Score@F System; 18: Safety Bus Routing for the Transportation of Pupils to School; 19: Spreading Awareness of Traffic Safety through Web Application; 20: Overview of Freight Train Derailments in the EU: Causes, Impacts, Prevention and Mitigation Measures; 21: A Risk Assessment Tool for Public Transportation; 22: The GETAWAY Project - Improving Passenger Evacuation Techniques in Railway Stations (and Other Transport Hubs) |
23: Interpretive Structural Modeling of Security Systems for Better Security Management in Railways1.1. Introduction; 1.2. Methodology; 1.3. Qualitative analyses of road safety management systems in Europe; 1.4. Quantitative analyses; 1.5. Conclusion; 1.6. Key messages and recommendations; 1.7. Acknowledgments; 1.8. Bibliography; 2.1. Introduction; 2.2. Methodological challenge: integration of different road safety concepts into territorial complex system modeling; 2.3. A practical example: ZIVAG; 2.4. Conclusion and followings; 2.5. Bibliography; 3.1. Introduction |
3.2. Data/knowledge collecting and processing |
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910811243903321 |
|
|
Titolo |
GPCR molecular pharmacology and drug targeting : shifting paradigms and new directions / / edited by Annette Gilchrist |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Hoboken, N.J., : Wiley, c2010 |
|
|
|
|
|
|
|
ISBN |
|
9786612685996 |
9781118035177 |
1118035178 |
9781282685994 |
1282685996 |
9780470627327 |
0470627328 |
9780470627310 |
047062731X |
|
|
|
|
|
|
|
|
Edizione |
[1st ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (544 p.) |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
G proteins |
Drug targeting |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
|
|
|
|
|
Nota di contenuto |
|
GPCR MOLECULAR PHARMACOLOGY AND DRUG TARGETING: SHIFTING PARADIGMS AND NEW DIRECTIONS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: The Evolution of Receptors: From On-Off Switches to Microprocessors; CHAPTER 2: The Evolving Pharmacology of GPCRs; CHAPTER 3: The Emergence of Allosteric Modulators for G Protein - Coupled Receptors; CHAPTER 4: Receptor-Mediated G Protein Activation: How, How Many, and Where?; CHAPTER 5: Molecular Pharmacology of Frizzleds-with Implications for Possible Therapy |
CHAPTER 6: Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled ReceptorsCHAPTER 7: Past and Future Strategies for GPCR Deorphanization; CHAPTER 8: High-Throughput GPCR Screening Technologies and the Emerging Importance of the Cell Phenotype; CHAPTER 9: Are "Traditional" Biochemical Techniques Out of Fashion in the New Era of GPCR |
|
|
|
|
|
|
|
|
|
|
|
Pharmacology?; CHAPTER 10: Fluorescence and Resonance Energy Transfer Shine New Light on GPCR Function; CHAPTER 11: Integration of Label-Free Detection Methods in GPCR Drug Discovery |
CHAPTER 12: Screening for Allosteric Modulators of G Protein-Coupled ReceptorsCHAPTER 13: Ultra-High-Throughput Screening Assays for GPCRs; CHAPTER 14: New Techniques to Express and Crystallize G Protein-Coupled Receptors; CHAPTER 15: Structure and Modeling of GPCRs: Implications for Drug Discovery; CHAPTER 16: X-Ray Structure Developments for GPCR Drug Targets; CHAPTER 17: Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors; INDEX |
|
|
|
|
|
|
Sommario/riassunto |
|
G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference. |
|
|
|
|
|
|
|
| |