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1. |
Record Nr. |
UNINA9910141254203321 |
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Titolo |
ADME-enabling technologies for drug design and development [[electronic resource] /] / edited by Donglu Zhang, Sekhar Surapaneni |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley, c2012 |
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ISBN |
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1-280-59257-5 |
9786613622402 |
1-118-18076-3 |
1-118-18077-1 |
1-118-18074-7 |
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Descrizione fisica |
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1 online resource (623 p.) |
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Altri autori (Persone) |
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ZhangDonglu |
SurapaneniSekhar |
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Disciplina |
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Soggetti |
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Drugs - Design |
Drug development |
Drugs - Metabolism |
Pharmaceutical chemistry |
Pharmacokinetics |
Pharmaceutical technology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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ADME-Enabling Technologies in Drug Design and Development; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; PART A: ADME: OVERVIEW AND CURRENT TOPICS; 1: REGULATORY DRUG DISPOSITION AND NDA PACKAGE INCLUDING MIST; 1.1 INTRODUCTION; 1.2 NONCLINICAL OVERVIEW; 1.3 PK; 1.4 ABSORPTION; 1.5 DISTRIBUTION; 1.5.1 Plasma Protein Binding; 1.5.2 Tissue Distribution; 1.5.3 Lacteal and Placental Distribution Studies; 1.6 METABOLISM; 1.6.1 In vitro Metabolism Studies; 1.6.2 Drug-Drug Interaction Studies; 1.6.3 In vivo Metabolism (ADME) Studies; 1.7 EXCRETION; 1.8 IMPACT OF METABOLISM INFORMATION ON LABELING |
1.9 CONCLUSIONSREFERENCES; 2: OPTIMAL ADME PROPERTIES FOR CLINICAL CANDIDATE AND INVESTIGATIONAL NEW DRUG (IND) |
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PACKAGE; 2.1 INTRODUCTION; 2.2 NCE AND INVESTIGATIONAL NEW DRUG (IND) PACKAGE; 2.3 ADME OPTIMIZATION; 2.3.1 Absorption; 2.3.2 Metabolism; 2.3.3 PK; 2.4 ADME OPTIMIZATION FOR CNS DRUGS; 2.5 SUMMARY; REFERENCES; 3: DRUG TRANSPORTERS IN DRUG INTERACTIONS AND DISPOSITION; 3.1 INTRODUCTION; 3.2 ABC TRANSPORTERS; 3.2.1 Pgp (MDR1, ABCB1); 3.2.2 BCRP (ABCG2); 3.2.3 MRP2 (ABCC2); 3.3 SLC TRANSPORTERS; 3.3.1 OCT1 (SLC22A1) and OCT2 (SLC22A2); 3.3.2 MATE1 (SLC47A1) and MATE2K (SLC47A2) |
3.3.3 OAT1 (SLC22A6) and OAT3 (SLC22A8)3.3.4 OATP1B1 (SLCO1B1, SLC21A6), OATP1B3 (SLCO1B3, SLC21A8), and OATP2B1 (SLCO2B1, SLC21A9); 3.4 IN VITRO ASSAYS IN DRUG DEVELOPMENT; 3.4.1 Considerations for Assessing Candidate Drugs as Inhibitors; 3.4.2 Considerations for Assessing Candidate Drugs as Substrates; 3.4.3 Assay Systems; 3.5 CONCLUSIONS AND PERSPECTIVES; REFERENCES; 4: PHARMACOLOGICAL AND TOXICOLOGICAL ACTIVITY OF DRUG METABOLITES; 4.1 INTRODUCTION; 4.2 ASSESSMENT OF POTENTIAL FOR ACTIVE METABOLITES; 4.2.1 Detection of Active Metabolites during Drug Discovery |
4.2.2 Methods for Assessing and Evaluating the Biological Activity of Metabolite Mixtures4.2.3 Methods for Generation of Metabolites; 4.3 ASSESSMENT OF THE POTENTIAL TOXICOLOGY OF METABOLITES; 4.3.1 Methods to Study the Formation of Reactive Metabolites; 4.3.2 Reactive Metabolite Studies: In vitro; 4.3.3 Reactive Metabolite Studies: In vivo; 4.3.4 Reactive Metabolite Data Interpretation; 4.3.5 Metabolite Contribution to Off-Target Toxicities; 4.4 SAFETY TESTING OF DRUG METABOLITES; 4.5 SUMMARY; REFERENCES |
5: IMPROVING THE PHARMACEUTICAL PROPERTIES OF BIOLOGICS IN DRUG DISCOVERY: UNIQUE CHALLENGES AND ENABLING SOLUTIONS5.1 INTRODUCTION; 5.2 PHARMACOKINETICS; 5.3 METABOLISM AND DISPOSITION; 5.4 IMMUNOGENICITY; 5.5 TOXICITY AND PRECLINICAL ASSESSMENT; 5.6 COMPARABILITY; 5.7 CONCLUSIONS; REFERENCES; 6: CLINICAL DOSE ESTIMATION USING PHARMACOKINETIC/PHARMACODYNAMIC MODELING AND SIMULATION; 6.1 INTRODUCTION; 6.2 BIOMARKERS IN PK AND PD; 6.2.1 PK; 6.2.2 PD; 6.2.3 Biomarkers; 6.3 MODEL-BASED CLINICAL DRUG DEVELOPMENT; 6.3.1 Modeling; 6.3.2 Simulation; 6.3.3 Population Modeling |
6.3.4 Quantitative Pharmacology (QP) and Pharmacometrics |
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Sommario/riassunto |
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A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible rang |
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2. |
Record Nr. |
UNINA9910822651003321 |
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Autore |
Karamanou Ioanna |
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Titolo |
Euripides, Alexandros : introduction, text and commentary / / by Ioanna Karamanou |
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Pubbl/distr/stampa |
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Berlin, [Germany] ; ; Boston, [Massachusetts] : , : De Gruyter, , 2018 |
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©2018 |
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ISBN |
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Descrizione fisica |
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1 online resource (398 pages) |
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Collana |
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Texte und Kommentare ; ; 57 |
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Disciplina |
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Soggetti |
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LITERARY CRITICISM / Ancient & Classical |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Frontmatter -- Preface -- Table of Contents -- Abbreviations -- Introduction -- Text -- Testimonia -- Fragmenta -- Fragmenta incertae sedis -- Fragments of uncertain location -- Fragmenta quae probabiliter ad Euripidis Alexandrum pertinent -- Fragments probably belonging to Euripides' Alexandros -- Commentary -- Appendix -- Bibliography -- General Index -- Index of Passages Discussed -- Plates |
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Sommario/riassunto |
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This is the first full-scale commentary on Euripides' Alexandros, which is one of the best preserved fragmentary tragedies. It yields insight into aspects of Euripidean style, ideology and dramatic technique (e.g. rhetoric, stagecraft and imagery) and addresses textual and philological matters, on the basis of a re-inspection of the papyrus fragments. This book offers a reconstruction of the play and an investigation of issues of characterization, staging, textual transmission and reception, not least because Alexandros has enjoyed a fascinating Nachleben in literary, dramaturgical and performative terms. It also contributes to the readers' understanding of the trends of later Euripidean drama, especially the dramatist's innovation and experimentation with plot-patterns and staging conventions. Furthermore, the analysis of Alexandros could stimulate a more comprehensive reading of the extant Trojan Women coming from the same production, which bears the features of a 'connected trilogy'. Thus, the information retrieved through the interrogation of the rich fragmentary material serves to supplement and contextualize the extant tragic corpus, showcasing the |
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vitality and multiformity of Euripidean drama as a whole. |
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