1.

Record Nr.

UNINA9910822628703321

Titolo

Elemental speciation in human health risk assessment / / first draft prepared by P. Apostoli ... [et al.]

Pubbl/distr/stampa

Geneva, : World Health Organization, 2006

ISBN

1-281-30751-3

9786611307516

92-4-068249-X

Edizione

[1st ed.]

Descrizione fisica

1 online resource (256 p.)

Collana

Environmental health criteria, , 0250-863X ; ; 234

Altri autori (Persone)

ApostoliP (Pietro)

Disciplina

615.9515

Soggetti

Trace elements - Speciation

Health risk assessment

Biological monitoring

Bioavailability

Analytical toxicology

Chemical elements - Physiological effect

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

TITLE; COPYRIGHT; CONTENTS; NOTE TO READERS OF THE CRITERIA MONOGRAPHS; PREAMBLE; WHO TASK GROUP ON ENVIRONMENTAL HEALTH CRITERIA FOR ELEMENTAL SPECIATION IN HUMAN HEALTH RISK ASSESSMENT; ACRONYMS AND ABBREVIATIONS; 1. SUMMARY; 2. DEFINITIONS OF SPECIES AND SPECIATION; 3. STRUCTURAL ASPECTS OF SPECIATION; 4. ANALYTICAL TECHNIQUES AND METHODOLOGY; 5. BIOACCESSIBILITY AND BIOAVAILABILITY; 6. TOXICOKINETICS AND BIOLOGICAL MONITORING; 7. MOLECULAR AND CELLULAR MECHANISMS OF METAL TOXICITY; 8. HEALTH EFFECTS; 9. CONCLUSIONS AND RECOMMENDATIONS; REFERENCES; RESUME; RESUMEN; INDEX OF ELEMENTS;

Sommario/riassunto

The purpose of this book is to assess, evaluate, and give guidance on



the role of elemental speciation and speciation analysis in human health hazard and risk assessment. The book is directed at risk assessors and regulators, to emphasize the importance of consideration of speciation in their deliberations. To date, this issue has not been a part of most hazard and risk assessments. Further aims of the publication are to encourage the analysis of speciation of elements to increase knowledge on the effect of speciation on mode of action and to increase understanding of health effects.