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Record Nr. |
UNINA9910822425603321 |
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Autore |
Migeon Barbara R |
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Titolo |
Females are mosaics : X inactivation and sex differences in disease / / Barbara R. Migeon |
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Pubbl/distr/stampa |
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Oxford : , : Oxford University Press, , [2014] |
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©2014 |
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ISBN |
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0-19-934366-7 |
0-19-992754-5 |
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Edizione |
[Second edition.] |
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Descrizione fisica |
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1 online resource (328 p.) |
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Disciplina |
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Soggetti |
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Mosaicism |
X chromosome - Abnormalities |
Genetic disorders |
Sex factors in disease |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Sex differences in disease -- Evolution of the human sex chromosomes and a portrait of the human X -- X chromosome dosage compensation : an overview -- The discovery of X chromosome inactivation -- Experimental models for X inactivation studies -- Theme 1 : the initial step : creating the active and inactive X -- Theme 2 : subsequent steps : spreading and maintaining inactivation -- Variations 1 : evolution of the X inactivation center -- Variations 2 : stability of the inactive X -- Variations 3 : choice of active X -- The single active X -- Mosaicism -- Epimutations, chromatin disorders and sex differences in phenotype -- Determinants of female phenotypes. |
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Sommario/riassunto |
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Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome, females have two X chromosomes in every cell. Much has been written about the Y chromosome and its role in inducing maleness. This is the only book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. This new edition reflects research advances from the six years since the widely praised first |
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