Analysis and purification methods in combinatorial chemistry / / edited by Bing Yan

• Record Nr.: UNINA9910821997503321
• Pubbl/distr/stampa: Hoboken, N.J., : Wiley-Interscience, 2004
• ISBN: 9780471531995; 9786610367856; 9781280367854; 1280367857; 9780470342930; 0470342935; 9780471531999; 0471531995; 9780471531975; 0471531979
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (xiii, 466 pages) : illustrations
• Collana: Chemical analysis ; ; v. 163
• Altri autori (Persone): YanBing
• Disciplina: 615/.19
• Soggetti: Combinatorial chemistry
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Analysis and Purification Methods in Combinatorial Chemistry; CONTENTS; PREFACE; CONTRIBUTORS; PART I ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS; CHAPTER 1 QUANTITATIVE ANALYSIS IN ORGANIC SYNTHESIS WITH NMR SPECTROSCOPY; CHAPTER 2 (19)F GEL-PHASE NMR SPECTROSCOPY FOR REACTION MONITORING AND QUANTIFICATION OF RESIN LOADING; CHAPTER 3 THE APPLICATION OF SINGLE-BEAD FTIR AND COLOR TEST FOR REACTION MONITORING AND BUILDING BLOCK VALIDATION IN COMBINATORIAL LIBRARY SYNTHESIS; CHAPTER 4 HR-MAS NMR ANALYSIS OF COMPOUNDS ATTACHED TO POLYMER SUPPORTS; CHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME MONITORING AND OPTIMIZATION OF COMBINATORIAL MATERIALS AND PROCESS CONDITIONS; CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE POLYMERIC SUPPORT; PART II HIGH-THROUGHPUT ANALYSIS FOR ; LIBRARY QUALITY CONTROL; CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES FOR COMBINATORIAL CHEMICAL LIBRARY ANALYSIS; CHAPTER 8 MICELLAR ELECTROKINETIC CHROMATOGRAPHY AS A TOOL FOR COMBINATORIAL CHEMISTRY ANALYSIS: THEORY AND APPLICATIONS; CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL ENCODED COMBINATORIAL LIBRARIES; PART III HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY; CHAPTER 10 STRATEGIES AND METHODS FOR PURIFYING ORGANIC COMPOUNDS AND COMBINATORIAL LIBRARIES; CHAPTER 11 HIGH-THROUGHPUT PURIFICATION: TRIAGE AND OPTIMIZATION; CHAPTER 12 PARALLEL HPLC IN HIGH-THROUGHPUT ANALYSIS AND PURIFICATION; PART IV ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY; CHAPTER 13 ORGANIC COMPOUND STABILITY IN LARGE, DIVERSE PHARMACEUTICAL SCREENING COLLECTION; CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN BIOMOLECULAR RECOGNITION; CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICAL PROFILING: POTENTIAL AND LIMITATIONS; CHAPTER 16 SOLUBILITY IN THE DESIGN OF COMBINATORIAL LIBRARIES; CHAPTER 17 HIGH-THROUGHPUT DETERMINATION OF LOG D VALUES BY LC/MS METHODINDEX
• Sommario/riassunto: Quality measurement, control, and improvement in combinatorial chemistryCombinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are ""purifiable,"" and ""drugable.""To this end, Analysis and Purification Methods in Combinatorial Chemistry