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Record Nr. |
UNINA9910777728603321 |
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Titolo |
Mathematical aspects of nonlinear dispersive equations [[electronic resource] /] / Jean Bourgain, Carlos E. Kenig, and S. Klainerman, editors |
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Pubbl/distr/stampa |
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Princeton, : Princeton University Press, 2007 |
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ISBN |
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1-282-12960-0 |
9786612129605 |
1-4008-2779-5 |
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Edizione |
[Course Book] |
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Descrizione fisica |
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1 online resource (309 p.) |
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Collana |
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Annals of mathematics studies ; ; no. 163 |
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Classificazione |
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Altri autori (Persone) |
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BourgainJean <1954-> |
KenigCarlos E. <1953-> |
KlainermanSergiu <1950-> |
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Disciplina |
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Soggetti |
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Differential equations, Nonlinear |
Nonlinear partial differential operators |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Frontmatter -- Contents -- Preface -- Chapter 1. On Strichartz's Inequalities and the Nonlinear Schrödinger Equation on Irrational Tori / Bourgain, J. -- Chapter 2. Diffusion Bound for a Nonlinear Schrödinger Equation / Bourgain, J. / Wang, W.-M. -- Chapter 3. Instability of Finite Difference Schemes for Hyperbolic Conservation Laws / Bressan, A. / Baiti, P. / Jenssen, H. K. -- Chapter 4. Nonlinear Elliptic Equations with Measures Revisited / Brezis, H. / Marcus, M. / Ponce, A. C. -- Chapter 5. Global Solutions for the Nonlinear Schrödinger Equation on Three-Dimensional Compact Manifolds / Burq, N. / Gérard, P. / Tzvetkov, N. -- Chapter 6. Power Series Solution of a Nonlinear Schrödinger Equation / Christ, M. -- Chapter 7. Eulerian-Lagrangian Formalism and Vortex Reconnection / Constantin, P. -- Chapter 8. Long Time Existence for Small Data Semilinear Klein-Gordon Equations on Spheres / Delort, J.-M. / Szeftel, J. -- Chapter 9. Local and Global Wellposedness of Periodic KP-I Equations / Ionescu, A. D. / Kenig, C. E. -- Chapter 10. The Cauchy Problem for the Navier-Stokes Equations with Spatially Almost Periodic Initial Data / Giga, Y. / Mahalov, A. / Nicolaenko, B. -- Chapter 11. Longtime Decay Estimates for the |
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Schrödinger Equation on Manifolds / Rodnianski, I. / Tao, T. -- Contributors -- Index |
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Sommario/riassunto |
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This collection of new and original papers on mathematical aspects of nonlinear dispersive equations includes both expository and technical papers that reflect a number of recent advances in the field. The expository papers describe the state of the art and research directions. The technical papers concentrate on a specific problem and the related analysis and are addressed to active researchers. The book deals with many topics that have been the focus of intensive research and, in several cases, significant progress in recent years, including hyperbolic conservation laws, Schrödinger operators, nonlinear Schrödinger and wave equations, and the Euler and Navier-Stokes equations. |
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2. |
Record Nr. |
UNINA9910821073203321 |
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Titolo |
The drug development paradigm in oncology : proceedings of a workshop / / Amanda Wagner Gee [and three others], rapporteurs |
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Pubbl/distr/stampa |
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Washington, District of Columbia : , : The National Academies Press, , 2018 |
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©2018 |
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ISBN |
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0-309-45797-1 |
0-309-45795-5 |
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Descrizione fisica |
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1 online resource (122 pages) : illustrations (some color) |
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Disciplina |
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Soggetti |
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Clinical trials - United States |
Drug development - United States |
Developmental pharmacology - United States |
United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters. |
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Sommario/riassunto |
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"Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer |
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and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of efforts--by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)--to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop"-- |
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