Chinmedomics : the integration of serum pharmacochemistry and metabolomics to elucidate the scientific value of traditional Chinese medicine / / editor, Xijun Wang ; associate editors, Aihua Zhang, Hui Sun

• Record Nr.: UNINA9910820913903321
• Pubbl/distr/stampa: Amsterdam, [Netherlands] : , : Academic Press, , 2015; ©2015
• ISBN: 0-12-803118-2; 0-12-803117-4
• Descrizione fisica: 1 online resource (408 p.)
• Disciplina: 615.19
• Soggetti: Pharmaceutical chemistry; Medicine - China - Philosophy - History; Medicine, Oriental - Philosophy - History; China
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Cover; Title Page; Copyright Page; Contents; List of Contributors; About the Editor; Preface; Chapter 1 - Origin of Chinmedomics; 1.1 - Introduction; 1.2 - Application and Challenges of TCM; 1.3 - Metabolomics: An Overview; 1.4 - Process of the Serum Pharmacochemistry of TCM; 1.5 - Establishment and Evolution of Chinmedomics; 1.6 - Potential Value of Chinmedomics; 1.7 - Future Perspectives; References; Chapter 2 - Methods and Protocols of Chinmedomics; 2.1 - Introduction; 2.2 - Analytical Technologies; 2.3 - Sampling; 2.4 - Data Extraction and Analysis; 2.5 - Marker Identification and Validation2.6 - Correlation Analysis between Marker Metabolites and Absorbed Chemical Components; 2.7 - Goals for Chinmedomics; 2.7.1 - Biological Mechanisms of the TCM Syndrome; 2.7.2 - Pharmacological Effects of Formulae; 2.7.3 - Correlation Analysis of Formulae and Syndrome for Effective Substances; 2.8 - Chinmedomics for Yinchenhao Tang: A Case Study; ; 2.9 - Conclusions; References; Chapter 3 - Chinmedomics Advancing Drug Discovery and Development from Yinchenhao Tang; 3.1 - Introduction; 3.2 - Experimental Detail; 3.2.1 - Chemicals and Materials; 3.3.4 - Cell Test to Verify the Therapeutic Efficacy of the Correlated Chemical Components3.4 - Conclusions; Chapter 4 - Chinmedomics Approach Dissects Therapeutic Properties of ShenQiWan Acting on ShenYangXu Syndrome; 4.1 - Introduction; 4.2 - Experimental Detail; 4.2.1 - Chemicals and Materials; 4.2.2 - Metabolomics Study; 4.2.2.1 - Animal Handling; 4.2.2.2 - Sample Collection and Preparation; 4.2.2.3 - UPLC-Q-TOF-HDMS Analysis; 4.2.2.4 - Metabolic Profiling and Metabolite Analysis; 4.2.3 - Constituents Analysis In Vitro and In Vivo; 4.2.3.1 - Animals; 4.2.3.2 - Preparation of SQW Samples for Analysis