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Record Nr. |
UNINA9910820293303321 |
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Titolo |
Chemistry of bioconjugates : synthesis, characterization, and biomedical applications / / edited by Ravin Narain |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley, , 2014 |
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©2014 |
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ISBN |
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1-118-77637-2 |
1-118-77588-0 |
1-118-77640-2 |
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Descrizione fisica |
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1 online resource (495 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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CHEMISTRY OF BIOCONJUGATES; CONTENTS; PREFACE; CONTRIBUTORS; SECTION I GENERAL METHODS OF BIOCONJUGATION; 1 COVALENT AND NONCOVALENT BIOCONJUGATION STRATEGIES; 1.1 INTRODUCTION; 1.2 COVALENT BIOCONJUGATION STRATEGIES; 1.2.1 Carboxyl Modifications; 1.2.2 Carbonyl Functional Groups; 1.2.3 Amine Modifications; 1.2.4 Thiol Modifications; 1.2.5 Hydroxyl Modifications; 1.2.6 Native Chemical Ligation and Expressed Protein Ligation; 1.2.7 Cross-linking Reagents for Bioconjugation; 1.2.8 Bioorthogonal Reactions; 1.2.9 Bioconjugation Via Transition Metal-catalyzed/Mediated Reactions |
1.2.10 Other Covalent Bioconjugation Methods1.3 NONCOVALENT BIOCONJUGATION STRATEGIES; 1.3.1 Biotin-(Strept)Avidin System; 1.3.2 Electrostatic Interactions; 1.3.3 Metal-mediated Non-covalent Conjugation; 1.3.4 Hybridization Method; 1.4 CONCLUSIONS AND OUTLOOK; REFERENCES; SECTION II POLYMER BIOCONJUGATES; 2 BIOCONJUGATES BASED ON POLY(ETHYLENE GLYCOL)S AND POLYGLYCEROLS; 2.1 INTRODUCTION; 2.2 POLYETHYLENE GLYCOL-BASED BIOCONJUGATES; 2.2.1 PEG-protein Conjugates; 2.2.2 PEG-peptide Conjugates; 2.2.3 PEG-antibody Conjugates; 2.2.4 PEGylation of Cells and Tissues |
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2.2.5 PEG Conjugates of Oligonucleotides, Aptamers, and siRNAs2.2.6 PEG-drug Conjugates (PEG prodrugs); 2.2.7 PEGylation of Viruses; 2.3 LIMITATIONS OF PEG CONJUGATES; 2.4 POLYGLYCEROL-BASED CONJUGATES; 2.4.1 HPG-drug Conjugates; 2.4.2 HPG-peptide and Protein Conjugates; 2.4.3 HPG Glycoconjugates; 2.4.4 HPG-Red Blood Cell Conjugates for Antigen Protection; 2.5 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 SYNTHETIC POLYMER BIOCONJUGATE SYSTEMS; 3.1 INTRODUCTION; 3.2 PEPTIDE OR PROTEIN BIOCONJUGATION TECHNIQUES; 3.2.1 Conjugation with Amino Acid; 3.2.2 Conjugation with Peptide Chain |
3.2.3 Conjugation with Proteins3.3 CARBOHYDRATE BIOCONJUGATION TECHNIQUES; 3.4 CONJUGATION WITH NUCLEIC ACID; 3.5 CONJUGATION WITH DRUGS; 3.6 CONJUGATION WITH CONTRAST AGENTS; 3.6.1 Polymers for Magnetic Resonance Imaging; 3.6.2 Polymers for Optical Imaging; 3.6.3 Polymers for Nuclear imaging; 3.7 CONCLUSION AND PERSPECTIVE; REFERENCES; 4 NATURAL POLYMER BIOCONJUGATE SYSTEMS; 4.1 INTRODUCTION; 4.2 NATURAL POLYMER SYSTEMS; 4.2.1 Protein-origin Polymer Bioconjugates; 4.2.2 Polysaccharidic Polymer Bioconjugates; 4.3 CONCLUSION AND FUTURE DIRECTIONS; ACKNOWLEDGMENT; REFERENCES |
5 DENDRIMER BIOCONJUGATES: SYNTHESIS AND APPLICATIONS5.1 INTRODUCTION-DENDRIMERS FOR BIOCONJUGATE CHEMISTRY; 5.2 DENDRIMER-DRUG CONJUGATES; 5.2.1 Motivation for the Development of Dendrimer-Drug Conjugates; 5.2.2 Dendrimer-DOX Conjugates; 5.2.3 Dendrimer-MTX Conjugates; 5.2.4 Dendrimer-TAX Conjugates; 5.2.5 Dendrimer-NAC Conjugates; 5.2.6 Dendrimer-Sulfonic Acids; 5.3 DENDRIMER-CARBOHYDRATE CONJUGATES; 5.3.1 Motivation for the Development of Dendrimer-Carbohydrate Conjugates; 5.3.2 Dendrimer-Mannose Conjugates; 5.3.3 Dendrimer-Galactose Conjugates; 5.3.4 Dendrimer-AcNA Conjugates |
5.4 DENDRIMER CONJUGATES WITH IMAGING AGENTS |
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Sommario/riassunto |
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This book describes the chemistries involved in bioconjugation followed by an extensive review of all types of bioconjugates (polymers, dendrimers, nanoparticles, carbon nanotubes) reported in the literature for different bio-related applications. A section is devoted to the physico-chemical and biochemical properties of bioconjugates and implications in their uses. Finally, the book also provides a comprehensive account about the significance of bioconjugation - coverage that is lacking in many of the current resources available. |
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2. |
Record Nr. |
UNINA9910349342003321 |
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Autore |
Oleksiyenko Anatoly V |
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Titolo |
Academic Collaborations in the Global Marketplace / / by Anatoly V. Oleksiyenko |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
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ISBN |
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Edizione |
[1st ed. 2019.] |
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Descrizione fisica |
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1 online resource (248 pages) |
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Collana |
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Knowledge Studies in Higher Education, , 2566-8315 ; ; 6 |
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Disciplina |
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Soggetti |
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Education, Higher |
School management and organization |
International education |
Comparative education |
Knowledge management |
Globalization |
Higher Education |
Organization and Leadership |
International and Comparative Education |
Knowledge Management |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1. Linking Globally, Acting Locally: Changes and Challenges -- 2. Major Research University: A Case of Glonacal U -- 3. The Bureaucracy of Change: More Bureaucracy Than Change? -- 4. “Steering Core”: Strategy-Makers and Competing Agendas -- 5. “Developmental Periphery”: Embracing Markets, Defying Hierarchies -- 6. “Academic Heartland”: Epistemic Pressures, Entrepreneurial Responses -- 7. Synergies and Conflicts: Stimuli, Logistics, and Costs -- 8. Glonacality of Research Universities -- Appendices. . |
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Sommario/riassunto |
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This book explains why conflict between the institutional and human agencies is an unavoidable outcome of competing local, national and |
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global agendas at a major research university. It illustrates this by means of a case-study of Glonacal U, a university which belongs to the category of exceptional institutions that excel due to an established organizational culture of academic freedom, research excellence, shared governance, and intellectual leadership. The book shows how such a university may succumb to anxiety when neoliberal managers seek to exploit stakeholder doubts about university sufficiency, relevance, and performance in national and global markets and hierarchies of knowledge products and status goods. As top-down pressure for strategic choices in scientific partnerships increases at the world-class university, grassroots resistance to centralization increases also in order to remind the research university leaders that intellectual work and academic freedom are interdependent and central to building capacities for impactful global science. Productive global linkages are prerogative of academics who take full responsibility for success of project implementation and outcomes in scholarship and practice. |
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