1.

Record Nr.

UNINA9910819041603321

Titolo

Aromatic amino acids in the brain

Pubbl/distr/stampa

Amsterdam ; ; New York : , : Elsevier, , 1974

ISBN

9786613693815

9781280783425

1280783427

9780470720059

0470720050

9780470717721

0470717726

Edizione

[1st ed.]

Descrizione fisica

1 online resource (408 pages) : illustrations, maps

Collana

Ciba Foundation symposium (new series) ; ; 22

Disciplina

599/.01/88

Soggetti

Amino acids

Brain chemistry

Aromatic compounds

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

"Symposium on Aromatic Amino Acids in the Brain held at the Ciba Foundation on 15th-17th May, 1973"--Participants page.

Nota di bibliografia

Includes bibliographical references and indexes.

Nota di contenuto

Aromatic Amino Acids in the Brain; Contents; Chairman's introduction; Control of plasma amino acid concentrations; Discussion; Amino acid transport in the brain in vivo and in vitro; Discussion; Octopamine, phenylethanolamine, phenylethylamine and tryptamine in the brain; Discussion; Tyrosine aminotransferase in the brain; Discussion; Properties of pterin-dependent aromatic amino acid hydroxylases; Discussion; The in vivo estimation of rates of tryptophan and tyrosine hydroxylation: effects of alterations in enzyme environment and neuronal activity; Discussion

The regulation of tyrosine hydroxylase activity in adrenergic nervous tissue Discussion; Nutritional control of the synthesis of 5-hydroxytryptamine in the brain; Discussion; The transfer of tryptophan across the synaptosome membrane; Discussion; Tryptophan concentration in the brain; Serum free tryptophan: control of brain concentrations of tryptophan and of synthesis of 5-hydroxytryptamine;



Fatty acids and the disposition of tryptophan; Discussion of the three preceding papers

Monoamine metabolites in the cerebrospinal fluid: indicators of the biochemical status of monoaminergic neurons in the cerebral nervous system Discussion; Do tryptophan concentrations limit protein synthesis at specific sites in the brain?; Discussion; Aromatic amino acid supply and protein synthesis in the brain; Discussion; Effects of amino acid imbalance on amino acid utilization, protein synthesis and polyribosome function in cerebral cortex; Discussion; L-Dopa, polysomal aggregation and cerebral synthesis of protein; Discussion; a-Methyldopa, an unnatural aromatic amino acid

Synthetic p-halogenophenylalanines and protein synthesis in the brain Discussion; Effects of a-methyltryptophan on tryptophan, 5-hydroxytryptamine and protein metabolism in the brain; Discussion; Chairman's closing remarks; Index of contributors; Subject index

Sommario/riassunto

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.