Protein degradation in health and disease

• Record Nr.: UNINA9910819037703321
• Pubbl/distr/stampa: Amsterdam ; ; New York : , : Excerpta Medica, , 1980
• ISBN: 9786613694324; 9781280783937; 1280783931; 9780470720585; 0470720581; 9780470718261; 0470718269
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (430 pages) : illustrations
• Collana: Ciba Foundation symposium ; ; 75 (new ser.)
• Disciplina: 616.3/995
• Soggetti: Proteins - Metabolism; Proteolytic enzymes; Physiology, Pathological
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Protein Degradation in Health and Disease; Contents; Discussion; Introduction: the classification of proteinases; Discussion; Lysosomal cysteine proteinases; Discussion; Cathepsin D: the lysosomal aspartic proteinase; Discussion; Human leucocyte elastase and cathepsin G: structural and functional characteristics; Discussion; Human collagenases: comparative and immunolocalization studies; Discussion; Proteinases in connective tissue breakdown; Discussion; Cellular mechanisms of proteinase release from inflammatory cells and the degradation of extracellular proteins; Discussion; Inactivation of cytosol enzymes by a liver membrane protein; Discussion; Lysosomes and protein degradation; Discussion; Insights into mechanisms of intracellular protein turnover from studies on pinocytosis; Discussion; Turnover and degradation of mitochondria and their proteins; Discussion; Protein degradation in cells in culture; Discussion; Regulation of protein breakdown in hepatocyte monolayers; ; Discussion; A possible role for neutral proteolysis in the degradation of intracellular proteins; Discussion; Studies of the ATP dependence of protein degradation in cells and cell extracts; Discussion; Coordination of protein synthesis and degradation; Discussion; General discussion Sites of protein degradation; Application of liver perfusion as an in vitro model in studies of intracellular protein degradation; Protein degradation and the regulation of protein balance in muscle; Discussion; Protein degradation in metabolic and nutritional disorders; Discussion; Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects; Discussion; Neutral proteinases of leucocytes and the inflammatory process; Discussion; Final general discussion; Concluding remarks; Index of contributors; Subject index
• Sommario/riassunto: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.