1.

Record Nr.

UNINA9910818862303321

Titolo

Polypeptide hormones : molecular and cellular aspects / / editors, F. G. Young [et al.]

Pubbl/distr/stampa

Amsterdam ; ; New York, : Elsevier, 1976

Amsterdam ; ; New York : , : Elsevier, , 1976

ISBN

9786613693938

9780470720233

0470720239

9781280783548

1280783540

9780470717912

0470717912

Edizione

[1st ed.]

Descrizione fisica

1 online resource (xii, 388 pages) : illustrations

Collana

Ciba Foundation symposium (new series) ; ; 41

Altri autori (Persone)

YoungFrank

Disciplina

599/.01/927

Soggetti

Peptide hormones

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

"Symposium on the Polypeptide Hormones: Molecular and Cellular Aspects held at the Ciba Foundation, London, 1st-3rd July, 1975"--Participants page.

"In honour of Sir Frank Young."

Nota di bibliografia

Includes bibliographical references and indexes.

Nota di contenuto

Polypeptide Hormones: molecular and cellular aspects -- Contents -- Chairman's opening remarks -- Biosynthesis of insulin and glucagon: a view of the current state of the art -- Discussion -- Molecular evolution of the polypeptide hormones -- Discussion -- Prohormones of β-melanotropin (β-melanocyte-stimulating hormone, β-MSH) and corticotropin (adrenocorticotropic hormone, ACTH) : structure and activation -- Discussion -- The nature of pituitary large growth hormone as studied by immunoabsorption -- Discussion -- Isolation of a biologically active messenger RNA : preparation from fish pancreatic islets by oligo(2'-deoxyrhymidylic acid) affinity chromatography -- Discussion -- The control of insulin release by sugars -- Discussion -- The mode of action of adenosine 3': 5'-cyclic phosphate in the regulation of insulin secretion -- Discussion -- Multiple forms of



corticotropin (adrenocorticotropic hormone, ACTH) and their significance -- Discussion -- Carboxypeptidase B-like and trypsin-like activities in isolated rat pancreatic islets -- Discussion -- New concepts in the formation, regulation of release, and metabolism of parathyroid hormone -- Discussion -- Structure and structure-function relationships in glycoprotein hormones -- Discussion -- Heterogeneity of the gastrins in blood and tissue -- Discussion -- Membrane topology as revealed by the binding of macromolecules -- Discussion -- Protein phosphorylation and hormone action -- Discussion -- Growth-promoting actions of peptide hormones -- Discussion -- General discussion I : Somatostatin-clinical implications Cells containing somatostatin in the pancreas and the gastrointestinal tract -- Gastrointestinal effects of somatostatin -- Somatostatin and diabetes mellitus -- General discussion II: Peptide metabolism -- Post-synthetic modification of peptides -- Secretion and processing.

Closing remarks -- Index of contributors -- Subject index.

Sommario/riassunto

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.