Endocannabinoids / / edited by Loren Parsons, Matthew Hill

• Record Nr.: UNINA9910818525803321
• Pubbl/distr/stampa: Amsterdam : , : Elsevier Science, , 2015
• ISBN: 0-12-801278-1; 0-12-801376-1
• Edizione: [First edition.]
• Descrizione fisica: 1 online resource (368 p.)
• Collana: International review of neurobiology, , 0074-7742 ; ; volume one hundred and twenty-five
• Soggetti: Cannabinoids; Cannabinoids - Receptors; Cannabinoids - Physiological effect
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Front Cover; Endocannabinoids; Copyright; Contents; Contributors; Preface; Chapter One: The Endocannabinoid Signaling System in the CNS: A Primer; 1. Introduction; 2. The Endocannabinoids; 2.1. Definitions; 2.2. Mechanisms of AEA Biosynthesis; 2.2.1. Precursor Synthesis; 2.2.2. NAPE Conversion to NAE: NAPE-PLD; 2.2.3. NAPE Conversion to NAE: Multienzyme Pathways; 2.2.4. AEA Synthesis from AA; 2.2.5. Summary; 2.3. Mechanisms of AEA Hydrolysis; 2.3.1. Fatty Acid Amide Hydrolase; 2.3.2. NAE-Hydrolyzing Acid Amidase: A Peripheral AEA Hydrolase; 2.4. Mechanisms of 2-AG Biosynthesis; 2.4.1. Diacylglycerol Lipase2.4.2. Mechanisms of DAG Synthesis; 2.5. Mechanisms of 2-AG Catabolism; 2.5.1. Monoacylglycerol Lipase; 2.5.2. Other Enzymes that Hydrolyze 2-AG in the Brain; 2.5.3. Contribution of 2-AG to AA Concentrations; 2.6. Other Inactivation Mechanisms for AEA and 2-AG; 2.6.1. Uptake, Accumulation, and Sequestration; 2.6.2. Oxygenation of the Arachidonate Backbone; 3. Endocannabinoid Receptors; 3.1. Introduction; 3.2. CB1 Cannabinoid Receptors; 3.2.1. CB1R Signaling; 3.2.2. CB1R Pharmacology; 4. CB1R and Retrograde Regulation of Synaptic Activity; 4.1. The Basic Paradigms; 4.1.1. Short-Term Depression of Synaptic Transmission4.1.2. Long-Term Depression of Transmission; 5. Summary; Acknowledgments; ; References; Chapter Two: Evidence for a Role of Adolescent Endocannabinoid Signaling in Regulating HPA Axis Stress Responsivity and E ...; 1. Adolescence and Pubertal Maturation; 2. The Neurobiology of Stress; 3. Adolescent HPA Axis Development; 4. The Developmental Influence of Gonadal Hormones on the HPA Axis; 5. The Endocannabinoid System; 6. Endocannabinoid System Regulation of the HPA Axis in Adulthood; 7. Ontogeny of the Endocannabinoid System; 8. Adolescent HPA Axis Function: A Regulatory Role for the Endocannabinoid System?8.1. Adolescent Stress Exposure Modulates Corticolimbic Endocannabinoid Signaling; 8.2. Adolescent Cannabinoid Exposure Modifies Adult Stress-Induced HPA Axis Activity; 8.3. Long-Term Consequences of Adolescent Endocannabinoid System Dysregulation on the Developing Brain and Behavior; 9. Concluding Remarks; Acknowledgments; References; Chapter Three: The Endocannabinoid System and Its Role in Regulating the Intrinsic Neural Circuitry of the Gastrointestin...; 1. Introduction; 2. The Enteric Nervous System and the Brain-Gut Axis2.1. The Structure of the ENS; 3. The Endocannabinoid System; 3.1. Cannabinoid Receptors and Their Ligands; 3.2. Cannabinoid Receptors in the ENS; 3.3. Endocannabinoid Synthesis; 3.4. 2-AG Synthesis and Degradation; 3.5. Anandamide Synthesis and Degradation; 4. Endocannabinoid Signaling Mechanisms; 4.1. Endocannabinoid Transport Mechanisms; 5. Other Receptors, Agonists, and Antagonists; 5.1. Phytocannabinoids; 5.2. Peptide Endocannabinoids; 5.3. Transient Receptor Potential Vanilloid 1; 5.4. Virodhamine, an Endogenous CB1 Antagonist; 5.5. G Protein-Coupled Receptor 55