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Record Nr. |
UNINA9910818329903321 |
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Autore |
Liebhoff Anna-Maria |
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Titolo |
Detection of pathogenic infections in neurological disorders through recycling of gene expression data / / Anna-Maria Liebhoff |
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Pubbl/distr/stampa |
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Göttingen : , : Cuvillier Verlag, , [2021] |
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©2021 |
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ISBN |
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Edizione |
[1. Auflage.] |
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Descrizione fisica |
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1 online resource (143 pages) |
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Disciplina |
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Soggetti |
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RNA viruses - Research - Methodology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Intro -- 1 Introduction -- 2 Biological background -- 2.1 Ribonucleic acid (RNA) -- 2.2 Small RNA -- 2.3 Sequencing -- 2.4 Microbiology -- 2.5 Neurodegenerative diseases -- 2.6 Pathogens in neurological diseases -- 3 Bioinformatics background -- 3.1 Data sources -- 3.2 Metadata and biological ontologies -- 3.3 Read alignment -- 3.4 Comparative analysis -- 3.5 Metagenomic analysis -- 3.6 Integrated analysis pipelines -- 4 Computer science background -- 4.1 Web development -- 4.2 Data science and machine learning -- 5 Small RNA Expression Atlas (SEA) -- 5.1 Background -- 5.2 System architecture -- 5.3 Implementation -- 5.4 System behavior -- 5.5 Results -- 6 Biological discoveries through SEA -- 6.1 Tissue specificity of small RNA -- 6.2 User data and Parkinson's disease -- 6.3 Pathogens in neurodegenerative diseases -- 6.4 Sex specificity of small RNA in human body -- 6.5 Discussion -- 7 Pathogen detection in RNA-seq data -- 7.1 Background -- 7.2 Identification algorithm -- 7.3 Performance measures -- 7.4 Evaluation -- 8 Path(ogen)s to disease -- 8.1 Analysis pipeline -- 8.2 Burkholderia stabilis in frontotemporal dementia -- 8.3 Discussion -- 9 Conclusion -- Bibliography -- A SEA JSON communication objects -- B Pathonoia algorithms -- C Detailed analysis results. |
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