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Record Nr. |
UNINA9910817713403321 |
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Titolo |
Dietary reference intakes : a risk assessment model for establishing upper intake levels for nutrients / / Food and Nutrition Board, Institute of Medicine |
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Pubbl/distr/stampa |
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Washington, D.C., : National Academy Press, 1998 |
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ISBN |
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0-309-17323-X |
1-280-18613-5 |
9786610186136 |
0-309-57080-8 |
0-585-05769-9 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (x, 71 pages) : illustrations |
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Collana |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Dietary Reference Intakes: A Risk Assessment Model for Establishing Upper Intake Levels for Nutrients -- Copyright -- Contents -- Dietary Reference Intakes: A Risk Assessment Model for Establishing Upper Intake Levels for Nutrients -- INTRODUCTION -- WHAT ARE DIETARY REFERENCE INTAKES? -- Recommended Dietary Allowance -- Process for Setting the RDA -- Adequate Intake -- Tolerable Upper Intake Level -- APPROACH FOR SETTING DIETARY REFERENCE INTAKES, INCLUDING TOLERABLE UPPER INTAKE LEVELS -- Terminology -- Concept -- MODEL FOR THE DERIVATION OF TOLERABLE UPPER INTAKE LEVELS -- RISK ASSESSMENT AND FOOD SAFETY -- Basic Concepts -- Steps in the Risk Assessment Process -- Thresholds -- APPLICATION OF THE RISK ASSESSMENT MODEL TO NUTRIENTS -- Special Problems Associated with Substances Required for Human Nutrition -- Consideration of Variability in Sensitivity -- Bioavailability -- Nutrient-Nutrient Interactions -- Other Relevant Factors Affecting Bioavailability of Nutrients -- STEPS IN THE DEVELOPMENT OF THE TOLERABLE UPPER INTAKE LEVEL -- Step 1. Hazard Identification -- Step 2. Dose- |
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Response Assessment -- Data Selection -- Identification of NOAEL (or LOAEL) and Critical Endpoint -- Uncertainty Assessment -- Characterization of the Estimate and Special Considerations -- DERIVATION OF ULS: SUMMARY OF PROGRESS TO DATE -- Derivation of UFs -- Derivation of a UL -- Derivation of a UL for Other Groups -- References -- Appendix A Recommended Dietary Intakes for Individuals -- Appendix B Options for Dealing with Uncertainties -- References -- Appendix C Reference Heights and Weights for Children and Adults -- Appendix D Case Studies of Application of Risk Assessment Model for Nutrients -- A. Calcium -- Hazard Identification -- Nephrolithiasis -- Hypercalcemia and Renal Insufficiency (Milk-Alkali Syndrome) -- Calcium/Mineral Interactions. |
Dose-Response Assessment -- Adults: Ages 19 through 70 Years -- Infants: Ages 0 through 12 Months -- Toddlers, Children, and Adolescents: Ages 1 through 18 years -- Older Adults: Ages > -- 70 Years -- Pregnancy and Lactation -- Special Considerations -- Exposure Assessment -- Risk Characterization -- References -- B. Folate -- Hazard Identification -- Adverse Effects -- Summary -- Dose-Response Assessment -- Adults -- Folate UL Summary, Adults -- Other Life Stage Groups -- Special Considerations -- Intake Assessment -- Risk Characterization -- References -- C. Riboflavin -- Hazard Identification -- Dose-Response Assessment -- Special Considerations -- Intake Assessment -- Risk Characterization -- References -- Appendix E Biographical Sketches of Subcommittee on Upper Reference Levels of Nutrients -- FNB Staff. |
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