| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910459923103321 |
|
|
Autore |
Cates James A. <1956-> |
|
|
Titolo |
Serving the Amish : a cultural guide for professionals / / James A. Cates |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Baltimore, Maryland : , : Johns Hopkins University Press, , 2014 |
|
©2014 |
|
|
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (251 p.) |
|
|
|
|
|
|
Collana |
|
Young Center Books in Anabaptist & Pietist Studies |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Amish - Services for |
Human services |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
""Cover""; ""Contents""; ""Preface""; ""Acknowledgments""; ""PART I: CULTURE AND CONTEXT""; ""CHAPTER 1. Strangers and Pilgrims""; ""PART II: LIFE EXPERIENCE""; ""CHAPTER 2. Changing Views of Human Services""; ""CHAPTER 3. Building and Maintaining Rapport""; ""CHAPTER 4. Across the Life Span""; ""CHAPTER 5. Women�s Issues""; ""CHAPTER 6. Sexuality""; ""CHAPTER 7. Violence and Abuse""; ""CHAPTER 8. Death and Loss""; ""PART III: PROFESSIONAL INTERACTION""; ""CHAPTER 9. Counseling and Psychotherapy""; ""CHAPTER 10. Substance Abuse and Addictions"" |
""CHAPTER 11. Law Enforcement and the Judiciary""""CHAPTER 12. Healthcare Professions""; ""CHAPTER 13. Social Work and Social Services""; ""PART IV: PRACTICAL CONSIDERATIONS""; ""CHAPTER 14. Guidelines for Service to the Amish""; ""Epilogue""; ""APPENDIX A: A Quick Guide to Other Plain Groups""; ""APPENDIX B: Mental Health Diagnoses and the Amish""; ""APPENDIX C: Suggestions for Further Reading""; ""Notes""; ""Bibliography""; ""Index""; ""A""; ""B""; ""C""; ""D""; ""E""; ""F""; ""G""; ""H""; ""I""; ""J""; ""K""; ""L""; ""M""; ""N""; ""O""; ""P""; ""Q""; ""R""; ""S""; ""T""; ""U""; ""V"" |
""W""""Y"" |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910437783403321 |
|
|
Autore |
Watson Arnold |
|
|
Titolo |
Geothermal engineering : fundamentals and applications / / Arnold Watson |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
New York : , : Springer, , 2013 |
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Edizione |
[1st ed. 2013.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (xviii, 336 pages) : illustrations (some color) |
|
|
|
|
|
|
Collana |
|
|
|
|
|
|
Disciplina |
|
621.042 |
624.15 |
624.151 |
628 |
|
|
|
|
|
|
|
|
Soggetti |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Introduction -- Sources of Geothermal Heat -- Thermodynamics Background and the Properties of Water -- The Equations Governing Heat and Single-Phase Fluid Flow and their Simplification for Particular Applications -- Geothermal Drilling and Well Design -- Well Measurements from Completion Tests to the First Discharge -- Phase Change Phenomena and Two-Phase Flow -- The Discharging Well -- The Transient Response of Formations to Flow in a Well – Transient Pressure Well Testing -- The Economics of a Geothermal Electricity Generation Project -- The Power Station -- The Steamfield -- The Resource Development Plan -- Struggles Between Commercial Uses and Conservation – Examples from New Zealand -- Appendix 1: Saturation Properties of Water from the Triple Point to the Critical Point -- Appendix 2: Compressibility of Water from 0-100°C and 0-1000 Bar -- Appendix 3: The Boiling-Point-for-Depth Curve. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
This book explains the engineering required to bring geothermal resources into use. The book covers specifically engineering aspects that are unique to geothermal engineering, such as measurements in wells and their interpretation, transport of near-boiling water through long pipelines, turbines driven by fluids other than steam, and project economics. The explanations are reinforced by drawing comparisons |
|
|
|
|
|
|
|
|
|
|
|
|
|
with other energy industries. This book also: Presents the only comprehensive treatment of geothermal engineering Connects problems and technologies of geothermal engineering to a variety of related topics in earth science, economics, and project oversight Covers techniques developed in the petroleum industry and explains these techniques at a fundamental level Includes material for practitioners and students of various engineering disciplines and earth scientists Geothermal Engineering: Fundamentals and Applications is appropriate in coverage and rigor for practitioners working in the energy and environmental resource sectors. The volume also finds an audience within the growing number of upper-division undergraduate and graduate courses in geothermal engineering and geothermal energy offered through various engineering departments and programs in earth science. |
|
|
|
|
|
|
3. |
Record Nr. |
UNINA9910817249603321 |
|
|
Autore |
Ghosh Arun K. |
|
|
Titolo |
Structure-based design of drugs and other bioactive molecules : tools and strategies / / Arun K. Ghosh and Sandra Gemma |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Weinheim, Germany : , : Wiley-VCH, , 2014 |
|
©2014 |
|
|
|
|
|
|
|
|
|
ISBN |
|
3-527-66523-4 |
3-527-66521-8 |
3-527-66524-2 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (476 p.) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Drug development - Data processing |
Bioactive compounds - Analysis |
Biopolymers |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references at the end of each chapters and index. |
|
|
|
|
|
|
|
|
Nota di contenuto |
|
Structure-based Design of Drugs and Other Bioactive Molecules: Tools |
|
|
|
|
|
|
|
|
|
|
|
and Strategies; Contents; Preface; 1 From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design; 1.1 Introduction; 1.2 Drug Discovery During 1928-1980; 1.3 The Beginning of Structure-Based Drug Design; 1.4 Conclusions; References; Part One: Concepts, Tools, Ligands, and Scaffolds for Structure-Based Design of Inhibitors; 2 Design of Inhibitors of Aspartic Acid Proteases; 2.1 Introduction; 2.2 Design of Peptidomimetic Inhibitors of Aspartic Acid Proteases |
2.3 Design of Statine-Based Inhibitors2.4 Design of Hydroxyethylene Isostere-Based Inhibitors; 2.5 Design of Inhibitors with Hydroxyethylamine Isosteres; 2.5.1 Synthesis of Optically Active α-Aminoalkyl Epoxide; 2.6 Design of (Hydroxyethyl)urea-Based Inhibitors; 2.7 (Hydroxyethyl)sulfonamide-Based Inhibitors; 2.8 Design of Heterocyclic/Nonpeptidomimetic Aspartic Acid Protease Inhibitors; 2.8.1 Hydroxycoumarin- and Hydroxypyrone-Based Inhibitors; 2.8.2 Design of Substituted Piperidine-Based Inhibitors; 2.8.3 Design of Diaminopyrimidine-Based Inhibitors |
2.8.4 Design of Acyl Guanidine-Based Inhibitors2.8.5 Design of Aminopyridine-Based Inhibitors; 2.8.6 Design of Aminoimidazole- and Aminohydantoin-Based Inhibitors; 2.9 Conclusions; References; 3 Design of Serine Protease Inhibitors; 3.1 Introduction; 3.2 Catalytic Mechanism of Serine Protease; 3.3 Types of Serine Protease Inhibitors; 3.4 Halomethyl Ketone-Based Inhibitors; 3.5 Diphenyl Phosphonate-Based Inhibitors; 3.6 Trifluoromethyl Ketone Based Inhibitors; 3.6.1 Synthesis of Trifluoromethyl Ketones; 3.7 Peptidyl Boronic Acid-Based Inhibitors |
3.7.1 Synthesis of α-Aminoalkyl Boronic Acid Derivatives3.8 Peptidyl α-Ketoamide- and α-Ketoheterocycle-Based Inhibitors; 3.8.1 Synthesis of α-Ketoamide and α-Ketoheterocyclic Templates; 3.9 Design of Serine Protease Inhibitors Based Upon Heterocycles; 3.9.1 Isocoumarin-Derived Irreversible Inhibitors; 3.9.2 β-Lactam-Derived Irreversible Inhibitors; 3.10 Reversible/Noncovalent Inhibitors; 3.11 Conclusions; References; 4 Design of Proteasome Inhibitors; 4.1 Introduction; 4.2 Catalytic Mechanism of 20S Proteasome; 4.3 Proteasome Inhibitors; 4.3.1 Development of Boronate Proteasome Inhibitors |
4.3.2 Development of β-Lactone Natural Product-Based Proteasome Inhibitors4.3.3 Development of Epoxy Ketone-Derived Inhibitors; 4.3.4 Noncovalent Proteasome Inhibitors; 4.4 Synthesis of β-Lactone Scaffold; 4.5 Synthesis of Epoxy Ketone Scaffold; 4.6 Conclusions; References; 5 Design of Cysteine Protease Inhibitors; 5.1 Introduction; 5.2 Development of Cysteine Protease Inhibitors with Michael Acceptors; 5.3 Design of Noncovalent Cysteine Protease Inhibitors; 5.4 Conclusions; References; 6 Design of Metalloprotease Inhibitors; 6.1 Introduction; 6.2 Design of Matrix Metalloprotease Inhibitors |
6.3 Design of Inhibitors of Tumor Necrosis Factor-α-Converting Enzymes |
|
|
|
|
|
|
Sommario/riassunto |
|
In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design.As a result, this practical book demonstrates how to develop a high-affinity ligand with drug-like properties for any given drug target for which a high-resolution structure exists. The authors, both of whom have successfully designed drug-like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in |
|
|
|
|
|
|
|
| |