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Record Nr. |
UNINA9910817147903321 |
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Titolo |
Cytochrome P450 function and pharmacological roles in inflammation and cancer / / edited by James P. Hardwick, S. J. Enna, Lynn Lecount ; contributors, Mohamed A. Abdelmegeed [and thirty-three others] |
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Pubbl/distr/stampa |
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Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
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©2015 |
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ISBN |
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0-12-803120-4 |
0-12-803119-0 |
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Edizione |
[First edition.] |
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Descrizione fisica |
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1 online resource (506 p.) |
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Collana |
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Advances in Pharmacology, , 1054-3589 ; ; Volume 74 |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Front Cover; Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer; Copyright; Contents; Contributors; Preface; References; Chapter One: Role of Cytochrome P450 Monooxygenase in Carcinogen and Chemotherapeutic Drug Metabolism; 1. Introduction; 2. Historical Aspects of Chemical Carcinogenesis Leading to Discovery of the Cytochrome P450 Monooxygenase; 2.1. Cytochromes P450; 2.2. Butter Yellow Carcinogenesis; 2.3. PAH Carcinogenesis: Protein Adducts and Induction of Metabolism |
3. Cytochrome P450-Monooxygenase-Mediated Activation of Procarcinogen and Chemotherapeutic Prodrugs3.1. Aromatic Azo Compounds; 3.2. Polycyclic Aromatic Hydrocarbons; 3.3. Polychlorinated Biphenyls; 3.3.1. Polychlorinated Biphenyls with Low Chlorine Content; 3.3.2. Highly Chlorinated Biphenyls; 3.4. Vinyl Chloride; 3.5. Nitrosamines; 3.6. Furans; 3.7. Chemotherapeutic Prodrugs; 3.7.1. Cyclophosphamide; 3.7.2. Procarbazine and Other Hydrazine Derivatives; 3.7.3. Anthracycline Antibiotics; 4. Factors That Regulate Changes in Gene Expression: Differences Between Rodents and Humans |
4.1. Hepatic Nuclear Receptors and Enzyme Induction4.2. Differences Between Rodent and Human Receptors; 4.3. CAR Splice Variants and |
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Ligand Specificity; 4.4. Exogenous Compounds Acting on the PPAR; 4.5. Underlying Regulation by Other Hormones and Transcription Factors; 4.6. Effects of Environmental Agents; 5. Polymorphic Cytochrome P450 Variants Impacting Expression and Cancer Susceptibility; 5.1. Cytochrome P4501A1 and Glutathione S-Transferase M1; 5.2. Cytochrome P4502D6 and Cytochrome P4502E1; 6. Conclusion; Conflict of Interest; Acknowledgment; References |
Chapter Two: Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer1. Introduction; 2. Reactive Oxygen Species Formation in Biological Systems; 2.1. Oxygen Reactivity and Formation of Reactive Oxygen Species; 2.2. Types of Reactive Oxygen Species and Their Reactivities; 2.2.1. Superoxide Radical Anion; 2.2.2. Hydrogen Peroxide; 2.2.3. Hydroxyl Radical; 2.2.4. Peroxyl Radical; 2.2.5. Singlet Oxygen; 3. Protective Agents to Combat Reactive Oxygen Species; 3.1. Antioxidants; 3.1.1. Antioxidant Enzymes; 3.1.2. Nonenzymatic Antioxidants; 3.1.2.1. Glutathione |
3.1.2.2. Vitamin E, Vitamin C, and β-Carotene3.1.2.3. Lycopene; 3.1.2.4. Melatonin; 4. CYP Catalytic Cycle and Involvement of CYP Enzymes in Reactive Oxygen Species Formation; 5. Roles of Reactive Oxygen Species in Cancer; 5.1. Reactive Oxygen Species and Cell Signaling; 6. Relationship Between CYP Enzymes and Cancer; 6.1. CYP Expression in Neoplastic Tissues; 6.2. CYP Polymorphism and Cancer Risk; 6.3. CYP Enzymes and Chemical Carcinogenesis; 6.4. CYP Enzymes and Cancer Therapy; 7. Conclusion; Conflict of Interest; Acknowledgments; References |
Chapter Three: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases |
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Sommario/riassunto |
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<i> Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer</i>, the latest volume in the <i>Advances in Pharmacology</i> series, presents not only the function of cytochrome P450 but also its pharmacological roles in inflammation and cancer. <br><br><ul><li>Contains contributions from the best authors in the field</li><li>Ideal reference for those conducting research in cancer, inflammation, cytochrome P450, metabolism, liver disease, and oxidative stress</li><li>Provides an essential resource for pharmacologists, immunologists, and biochemists</li></ul> |
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