Cellular senescence [[electronic resource] ] : implications for cancer therapy / / Razmik Mirzayans and David Murray

• Record Nr.: UNINA9910817000303321
• Autore: Mirzayans Razmik
• Pubbl/distr/stampa: New York, : Nova Biomedical Books, c2009
• ISBN: 1-61728-173-5
• Edizione: [1st ed.]
• Descrizione fisica: 113 p. : ill. (some col.)
• Altri autori (Persone): MurrayDavid, Ph. D.
• Soggetti: Cells - Aging; Cancer - Treatment
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Bibliographic Level Mode of Issuance: Monograph
• Nota di bibliografia: Includes bibliographical references (p. [75]-100) and index.
• Nota di contenuto: Intro -- CELLULAR SENESCENCE: IMPLICATIONS FOR CANCER THERAPY -- CELLULAR SENESCENCE: IMPLICATIONS FOR CANCER THERAPY -- CONTENTS -- PREFACE -- Chapter 1 INTRODUCTION -- Chapter 2 TELOMERASE-BASED SENESCENCE -- Chapter 3 STRESS-TRIGGERED PREMATURE SENESCENCE -- Chapter 4 FEATURES OF PREMATURE SENESCENCE -- CELL MORPHOLOGY -- SENESCENCE-ASSOCIATED β-GALACTOSIDASE EXPRESSION -- SUSTAINED P21 UP-REGULATION -- INHIBITION OF CELL GROWTH -- NUCLEAR ACCUMULATION OF ACTIN -- STRESS-ASSOCIATED NUCLEAR FOCI -- Chapter 5 DIFFERENT MODES OF GROWTH ARREST ARE TRIGGERED BY GENOTOXIC STRESS -- Chapter 6 CLASSIFICATION OF CDK INHIBITORS -- Chapter 7 ROLES OF P21, P53 AND P16 IN SENESCENCE -- Chapter 8 REGULATION OF P21WAF1 TRANSCRIPT AND P21 PROTEIN LEVELS -- Chapter 9 MODE OF ACTION OF P21 -- Chapter 10 P53 SIGNALING AND CELLULAR RESPONSE TO DNA-DAMAGING AGENTS -- IONIZING RADIATION-TRIGGERED RESPONSES -- UV-TRIGGERED RESPONSES -- APOPTOTIC THRESHOLD IN CANCER CELLS EXPOSED TO DNA-DAMAGING AGENTS -- WHAT FACTORS MIGHT CONTRIBUTE TO THE APOPTOTIC THRESHOLD? -- Chapter 11 CELL-TO-CELL COMMUNICATION TRIGGERED BY DNA-DAMAGING AGENTS -- ROS-ASSOCIATED BYSTANDER EFFECT OF RADIATION -- P53-MEDIATED BYSTANDER EFFECT OF RADIATION -- DIFFUSIBLE "AT-CORRECTING" FACTORS -- Chapter 12 MODULATING SENESCENCE IN THE CONTEXT OF CANCER ; THERAPY -- PROS AND CONS OF ACTIVATING SENESCENCE IN CANCER CELLS -- ASSAYS FOR PRECLINICAL TESTING OF ANTICANCER AGENTS -- Chapter 13 AGING, SENESCENCE, AND "HORMESIS" -- Chapter 14 HUMAN GENETIC DISORDERS ASSOCIATED WITH GENOMIC INSTABILITY AND CANCER PREDISPOSITION -- WERNER SYNDROME -- HUTCHINSON-GILFORD'S PROGERIA SYNDROME -- BLOOM SYNDROME -- ROTHMUND-THOMPSON SYNDROME -- COCKAYNE SYNDROME -- XERODERMA PIGMENTOSUM -- FANCONI ANEMIA -- ATAXIA TELANGIECTASIA -- LI-FRAUMENI SYNDROME.; Chapter 15 BIOLOGICAL CONSEQUENCES OF THE FAILURE OF CELLS TO UNDERGO SENESCENCE/APOPTOSIS FOLLOWING GENOTOXIC STRESS: BASIS FOR THE EMERGENCE OF HIGHLY METASTATIC AND THERAPY-RESISTANT DISEASE? -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- INDEX -- Blank Page.