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1. |
Record Nr. |
UNINA9910816781103321 |
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Titolo |
Protein phosphorylation in parasites : novel targets for antiparasitic intervention / / edited by Christian Doerig, Gerald Späth, and Martin Wiese |
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Pubbl/distr/stampa |
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Weinheim : , : Wiley Blackwell, , [2014] |
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©2014 |
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ISBN |
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3-527-67537-X |
3-527-67540-X |
3-527-67539-6 |
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Descrizione fisica |
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1 online resource (452 p.) |
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Collana |
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Drug discovery in infectious diseases ; ; volume 5 |
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Altri autori (Persone) |
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DoerigChristian |
SpäthGerald |
WieseMartin |
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Disciplina |
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Soggetti |
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Phosphoproteins - Synthesis |
Parasitology |
Parasites |
Antiparasitic agents |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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part one. Bioinformatics -- part two. Functional analysis of parasite kinomes and phosphatomes -- part three. Role of host cell kinomes and phosphatomes in parasitic infections -- part four. Drug discovery. |
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Sommario/riassunto |
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This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who?s Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two-volume treatise, the second |
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2. |
Record Nr. |
UNINA9910254514603321 |
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Autore |
Hutson John M |
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Titolo |
Descent of the Testis / / by John M. Hutson, Jørgen Mogens Thorup, Spencer W. Beasley |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
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ISBN |
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Edizione |
[2nd ed. 2016.] |
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Descrizione fisica |
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1 online resource (188 p.) |
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Disciplina |
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Soggetti |
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Pediatrics |
Human genetics |
Children - Surgery |
Human Genetics |
Pediatric Surgery |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters. |
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Nota di contenuto |
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Introduction -- Evolution of Descent of the Testis and Early History of Research -- Transabdominal Migration of the Testis -- InguinoScrotal Descent of the Testis -- Classification and Causes of Undescended Tested in Humans -- Cryptorchidism and Associated Anomalies -- The Postnatal Effects of Cryptorchidism -- Diagnosis of Undescended Testis -- Operative Treatment -- Hormonal Treatment -- Results of Treatment -- Conclusions and Future Development. |
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Sommario/riassunto |
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This book provides a state of the art overview of all aspects of testicular descent and cryptorchidism, including the mechanisms of descent and the causes, consequences, diagnosis, and treatment of undescended testis. The advances in understanding that have been achieved over the past two decades are clearly explained, covering the latest genetic information on the causes of normal and abnormal testicular descent, the role of INSL3 in transabdominal migration, and the evidence that a neurotransmitter released from the genitofemoral nerve mediates androgenic control of inguinoscrotal descent. Exciting changes in the management of both congenital and acquired cryptorchidism, such as the widespread use of laparoscopy for |
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impalpable testes inside the abdominal cavity, are fully described. Evidence for the benefits of orchidopexy within the first year of life is reviewed, and an individual chapter is also devoted to hormonal treatment. Throughout the book due attention is given to ongoing controversies and divergences of opinion. This new edition of Descent of the Testis will be a timely update and valuable reference for all who are involved in research into testicular descent and management of cryptorchidism. |
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