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Record Nr. |
UNINA9910816269003321 |
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Autore |
Julious Steven A |
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Titolo |
An introduction to statistics in early phase trials / / Steven Julious, Say-Beng Tan, David Machin |
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Pubbl/distr/stampa |
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Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley, 2010 |
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ISBN |
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9786612482779 |
9781282482777 |
1282482777 |
9780470686164 |
0470686162 |
9780470319178 |
0470319178 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (271 p.) |
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Altri autori (Persone) |
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MachinDavid <1939-> |
TanSay Beng |
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Disciplina |
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Soggetti |
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Drugs - Testing - Statistical methods |
Clinical trials - Statistical methods |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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An Introduction to Statistics in Early Phase Trials; Contents; Chapter 1 Early phase trials; Chapter 2 Introduction to pharmacokinetics; Chapter 3 Sample size calculations for clinical trials; Chapter 4 Crossover trial basics; Chapter 5 Multi-period crossover trials; Chapter 6 First time into man; Chapter 7 Bayesian and frequentist methods; Chapter 8 First-time-into-new-population studies; Chapter 9 Bioequivalence studies; Chapter 10 Other Phase I trials; Chapter 11 Phase II trials: general issues; Chapter 12 Dose-response studies; Chapter 13 Phase II trials with toxic therapies |
Chapter 14 Interpreting and applying early phase trial resultsChapter 15 Go/No-Go criteria; Appendix; References; Index |
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Sommario/riassunto |
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All new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. |
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