| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910143082803321 |
|
|
Autore |
Ferrer Imma <1970-> |
|
|
Titolo |
Liquid chromatography/time-of-flight mass spectrometry [[electronic resource] ] : principles, tools, and applications for accurate mass analysis / / Imma Ferrer, E.M. Thurman |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Hoboken, NJ, : Wiley, 2008 |
|
|
|
|
|
|
|
ISBN |
|
1-282-11306-2 |
9786612113062 |
0-470-42996-8 |
0-470-42995-X |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (281 p.) |
|
|
|
|
|
|
Collana |
|
Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications ; ; v.254 |
|
|
|
|
|
|
|
|
Altri autori (Persone) |
|
ThurmanE. M <1946-> (Earl Michael) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
Liquid chromatography |
Time-of-flight mass spectrometry |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
|
|
|
|
|
Nota di contenuto |
|
LIQUID CHROMATOGRAPHY TIME-OF-FLIGHT MASS SPECTROMETRY; CONTENTS; PREFACE; CONTRIBUTORS; PART I PRINCIPLES AND THEORETICAL ASPECTS OF ACCURATE MASS; CHAPTER 1 ACCURATE MASS MEASUREMENTS WITH ORTHOGONAL AXIS TIME-OF-FLIGHT MASS SPECTROMETRY; CHAPTER 2 THE MASS DEFECT, ISOTOPE CLUSTERS, AND ACCURATE MASS FOR ELEMENTAL DETERMINATION; PART II TOOLS FOR UNKNOWN IDENTIFICATION USING ACCURATE MASS; CHAPTER 3 ION COMPOSITIONS DETERMINED WITH INCREASING SIMPLICITY; CHAPTER 4 EXISTENCE AND USE OF ACCURATE MASS DATABASES AND ELEMENTAL COMPOSITION TOOLS FOR TARGET AND NON-TARGET ANALYSES |
CHAPTER 5 USE OF UPLC-(Q)TOF MS FOR RAPID SCREENING OF ORGANIC MICROPOLLUTANTS IN WATER CHAPTER 6 THE USE OF ACCURATE MASS, ISOTOPE RATIOS, AND MS/MS FOR THE ANALYSIS OF PPCPs IN WATER; PART III APPLICATIONS OF LC/TOF-MS FOR THE IDENTIFICATION OF SMALL MOLECULES; CHAPTER 7 APPLICATIONS OF |
|
|
|
|
|
|
|
|
|
|
|
LC/TOF-MS IN THE ENVIRONMENTAL FIELD: WHEN DID IT START AND WHERE IS IT GOING?; CHAPTER 8 LIQUID CHROMATOGRAPHY AND AMBIENT IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY FOR THE ANALYSIS OF GENUINE AND COUNTERFEIT PHARMACEUTICALS |
CHAPTER 9 QUANTITATIVE ANALYSIS OF VETERINARY DRUG RESIDUES BY SUB 2-μm PARTICULATE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY COLUMNS AND TIME-OF-FLIGHT MASS SPECTROMETRY (UPLC-TOF)CHAPTER 10 INDUSTRIAL APPLICATIONS OF LIQUID CHROMATOGRAPHY TIME-OF-FLIGHT MASS SPECTROMETRY; CHAPTER 11 COMPREHENSIVE TOXICOLOGICAL AND FORENSIC DRUG SCREENING BY LC/TOF-MS; CHAPTER 12 APPLICATION OF UPLC/TOF-MS FOR RESIDUE ANALYSIS OF VETERINARY DRUGS AND GROWTH-PROMOTING AGENTS IN PRODUCTS OF ANIMAL ORIGIN |
CHAPTER 13 ACCURATE MASS MEASUREMENTS WITH A REFLECTRON TIME-OF-FLIGHT MASS SPECTROMETER AND THE DIRECT ANALYSIS IN REAL TIME (DART) INTERFACE FOR THE IDENTIFICATION OF UNKNOWN COMPOUNDS BELOW MASSES OF 500 DACHAPTER 14 COMPARISON OF LC/TOF-MS AND LC/MS-MS FOR THE ANALYSIS OF 100 PESTICIDES IN FOOD: FINDING THE "CROSSOVER POINT""; INDEX |
|
|
|
|
|
|
Sommario/riassunto |
|
Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants-such as antibiotics, steroids, analgesics-using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910792343103321 |
|
|
Autore |
Halttunen Karen <1951-> |
|
|
Titolo |
Murder most foul [[electronic resource] ] : the killer and the American Gothic imagination / / Karen Halttunen |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Cambridge, Mass., : Harvard University Press, 1998 |
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (xiv, 322p., [32]p. of plates ) : ill., facsims., plan, ports |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Gothic revival (Literature) - United States |
Murder in literature |
Murder - United States |
Murder - United States - History |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Bibliographic Level Mode of Issuance: Monograph |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references (p. 253-312) and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Introduction 1. The Murderer as Common Sinner 2. The Birth of Horror 3. The Pornography of Violence 4. The Construction of Murder as Mystery 5. Murder in the Family Circle 6. Murdering Medusa 7. The Murderer as Mental Alien Epilogue Notes Index |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
In this text, Karen Halttunen explores the changing view of murder from early New England sermons read at the public executions, through to the true crime literature and tabloid reporting of the late 1990's. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3. |
Record Nr. |
UNINA9910816268703321 |
|
|
Titolo |
Critical pathways to success in CNS drug development / / Neal R. Cutler ... [et al.] |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Chichester, UK ; ; Hoboken, NJ, : Wiley-Blackwell, 2010 |
|
|
|
|
|
|
|
ISBN |
|
9786612491269 |
9781282491267 |
1282491261 |
9781444318579 |
1444318578 |
9781444318586 |
1444318586 |
|
|
|
|
|
|
|
|
Edizione |
[2nd ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (273 p.) |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Neuropsychopharmacology |
Drug development |
Critical path analysis |
Central nervous system - Effect of drugs on - Research - Methodology |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Critical Pathwaysto Success in CNSDrug Development; Contents; Acknowledgments; Foreword; 1 The impending crisis in CNS drug development; 2 Animal models and procedures for CNS disorders; 3 Preclinical antecedents to early human clinical trials; 4 Biomarkers and surrogate markers in drug development; 5 Neuroimaging and cognitive assessments in early drug development; 6 Bridging and CSF studies; 7 A case study from preclinical to early clinical trials; Index |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials. The current crisis in the drug development industry is |
|
|
|
|
|
|
|
|
|
|
critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development i |
|
|
|
|
|
| |