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1. |
Record Nr. |
UNINA9910815910703321 |
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Autore |
Kuznetsova Julia |
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Titolo |
Linguistic profiles : going from form to meaning via statistics / / Julia Kuznetsova |
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Pubbl/distr/stampa |
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Berlin : , : De Gruyter Mouton, , [2015] |
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©2015 |
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ISBN |
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3-11-039348-4 |
3-11-036185-X |
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Descrizione fisica |
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1 online resource (260 p.) |
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Collana |
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Cognitive linguistics research, , 1861-4132 ; ; volume 53 |
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Classificazione |
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Disciplina |
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Soggetti |
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Linguistics - Statistical methods |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Front matter -- Acknowledgements -- Table of content -- Note on corpora, statistical methods and databases -- List of abbreviations -- 1. Introduction -- 2. Linguistic profiles -- 3. Grammatical profiling and gender stereotypes -- 4. Semantic profiling, predictability and prototypicality -- 5. Constructional profiling and aspectual pairs -- 6. Collostructional profiling -- 7. Conclusion -- References -- Appendix -- Subject Index -- Index of Russian verbs |
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Sommario/riassunto |
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The monograph investigates the relationship between form and meaning in different domains and centers on a group of methods referred to as “linguistic profiles” that have been developed recently by researchers at the University of Tromsø. These methods are based on the observation that there is a strong correlation between semantic and distributional properties of linguistic units. This book discusses grammatical, semantic, constructional, collostructional and diachronic profiles. Linguistic profiles as a group of methods are based on recent developments in the area of cognitive and functional linguistics: 1) form in language always has a relation to meaning, 2) a categorical approach to language is replaced with an understanding of language as a gradient phenomenon, which is investigated via statistics, 3) grammar is seen as a usage-based phenomenon. Throughout the book we see that each of the profiles determines a correlation between certain forms and certain meanings. By studying the distribution of |
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different forms we can uncover the semantic restrictions standing behind them. |
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2. |
Record Nr. |
UNINA9910557287703321 |
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Autore |
Cecchin Erika |
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Titolo |
Pharmacogenomics and Personalized Medicine |
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Pubbl/distr/stampa |
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Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
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Descrizione fisica |
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1 online resource (208 p.) |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient's genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including a study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of inter-individual variability in drug metabolism. In this book, we have collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastructures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics. |
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