| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910813824403321 |
|
|
Autore |
Shenker Noah |
|
|
Titolo |
Reframing Holocaust testimony / / Noah Shenker |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Bloomington, Indiana ; ; Indianapolis, [Indiana] : , : Indiana University Press, , 2015 |
|
©2015 |
|
|
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (268 p.) |
|
|
|
|
|
|
Collana |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Holocaust, Jewish (1939-1945) - Influence |
Holocaust, Jewish (1939-1945) - Audio-visual aids |
Holocaust, Jewish (1939-1945) - Social aspects |
Oral history - Audio-visual aids |
Video recording - Influence |
Interviewing - Technique |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
"Institutions that have collected video testimonies from the few remaining Holocaust survivors are grappling with how to continue their mission to educate and commemorate. Noah Shenker calls attention to the ways that audiovisual testimonies of the Holocaust have been mediated by the institutional histories and practices of their respective archives. Shenker argues that testimonies are shaped not only by the encounter between interviewer and interviewee, but also by technical practices and the testimony process. He analyzes the ways in which interview questions, the framing of the camera, and curatorial and programming preferences impact how Holocaust testimony is molded, distributed, and received"--Provided by publisher. |
|
|
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
1. Testimonies from the Grassroots: The Fortunoff Video Archive for Holocaust Testimonies -- 2. Centralizing Holocaust Testimony: The United States Holocaust Memorial Museum -- 3. The Cinematic Origins and the Digital Future of the Shoah Foundation -- 4. Telling and Retelling Holocaust Testimonies. Conclusion: Documenting Genocide through the Lens of the Holocaust. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
Institutions that have collected video testimonies from the few |
|
|
|
|
|
|
|
|
|
|
|
|
|
remaining Holocaust survivors are grappling with how to continue their mission to educate and commemorate. Noah Shenker calls attention to the ways that audiovisual testimonies of the Holocaust have been mediated by the institutional histories and practices of their respective archives. Shenker argues that testimonies are shaped not only by the encounter between interviewer and interviewee, but also by technical practices and the testimony process. He analyzes the ways in which interview questions, the framing of the camera, and c |
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910346760003321 |
|
|
Autore |
Clévio Nóbrega |
|
|
Titolo |
Gene Silencing and Editing Strategies for Neurodegenerative Diseases |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (115 p.) |
|
|
|
|
|
|
Collana |
|
Frontiers Research Topics |
|
|
|
|
|
|
Soggetti |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Sommario/riassunto |
|
Neurodegenerative diseases (NDs) are a heterogeneous group of disorders affecting the central nervous system. Despite significant differences in their causes, neuropathological abnormalities, and clinical outcomes, some similarities can be found among them, as for example: 1) frequent aggregation and deposition of misfolded proteins, 2) common molecular mechanisms leading to neurodegeneration, and 3) certain overlap in symptoms and clinical features. To date, there is no cure that could stop or delay the progression of these diseases. The advent of advanced gene therapy techniques such as gene silencing and gene editing opened a new avenue for the development of therapeutic strategies for NDs. The discovery of the RNA interference (RNAi) mechanism, in 1998, by Andrew Fire and Craig Mello allowed an important boost to the gene therapy field, providing a potential |
|
|
|
|
|
|
|
|
|
|
therapeutic strategy to treat inherited dominant genetic disorders. The use of small RNA sequences to control the expression of disease-causing genes rapidly implemented in the preclinical studies for different diseases. In the field of NDs, several successful studies using this technology proved its potential as a therapeutic option. However, issues like the type of delivery system (non-viral versus viral) or the potential toxicity of the small RNA molecules, made the translation of gene silencing therapeutics to human application very slow and difficult. Recently, a new hope in the gene therapy field emerged with the development of gene editing techniques like TALENs or CRISPR/Cas9 systems. The opportunity of editing or deleting gene sequences drove the scientific community euphoric, with an enormous increase in the number of published studies using this type of techniques. Recently, the first clinical trial using one of these systems was approved in China. For NDs, gene-editing technology also represents an important therapeutic option, and the first preclinical studies are now being published, showing the potential accomplishment for this technology. |
|
|
|
|
|
| |