Nanoparticulates as drug carriers / / editor, Vladimir P. Torchilin

• Record Nr.: UNINA9910813580403321
• Pubbl/distr/stampa: London, : Imperial College Press, c2006
• ISBN: 1-281-86744-6; 9786611867447; 1-86094-907-X
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (756 pages)
• Altri autori (Persone): TorchilinV. P
• Disciplina: 615.6
• Soggetti: Nanoparticles; Nanostructured materials; Biomedical materials
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Contributors ; 1. Introduction. Nanocarriers for Drug Delivery: Needs and Requirements ; References ; 2. Nanoparticle Flow: Implications for Drug Delivery ; 1 Introduction ; 2 Background ; 3 Studies on Nanoparticle Flow ; 4 Convection and Diffusion ; 5 Bifurcations. 6 Interaction with Blood Constituents and Endogenous Molecules 7 Nanoparticles with Surface Ligands ; 8 Deposition on Surfaces and Attachment to Receptors in Flow Conditions ; 9 Does Shape Matter? ; 10 Speculations on Flow and the EPR Effect ; 11 Intra-tumoral Injection. 12 Conclusions References ; 3. Polymeric Nanoparticles as Drug Carriers and Controlled Release Implant Devices ; 1 Introduction ; 2 Nanoparticle Engineering ; 3 Site-specific Targeting with Nanoparticles: Importance of Size and Surface Properties ; 4 Conclusions ; References. 4. Genetic Vaccines: A Role for Liposomes 1 Introduction ; 2 The DNA Vaccine ; 3 DNA Vaccination via Liposomes ; 4 The Co-delivery Concept ; References ; 5. Polymer Micelles as Drug Carriers ; 1 Introduction ; 2 Polymer Micelle Structures ; 3 Drug Loading and Release. 4 Pharmacokinetics and Biodistribution 5 Drug Delivery Applications ; 6 Clinical Trials ; 7 Conclusions ; References ; 6. Vesicles Prepared from Synthetic Amphiphiles; Polymeric Vesicles and Niosomes ; 1 Introduction ; 2 Polymeric Vesicles
• Sommario/riassunto: Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications.