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Record Nr. |
UNINA990000003070403321 |
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Autore |
Bonfiglio, Michele |
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Titolo |
Il motore diesel in azione / Michele Bonfiglio |
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Pubbl/distr/stampa |
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Torino : Società subalpina editrice, 1941 |
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Descrizione fisica |
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XV, 702 p. : ill. ; 25 cm |
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Disciplina |
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Locazione |
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Collocazione |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9910813373503321 |
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Titolo |
Functional metabolism : regulation and adaptation / / edited by Kenneth B. Storey |
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Pubbl/distr/stampa |
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Hoboken, N.J., : John Wiley & Sons, c2004 |
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ISBN |
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9786610252848 |
9781280252846 |
1280252847 |
9780470355251 |
0470355255 |
9780471675570 |
0471675571 |
9780471675587 |
047167558X |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (614 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Metabolism - Regulation |
Homeostasis |
Adaptation (Physiology) |
Cellular signal transduction |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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FUNCTIONAL METABOLISM: REGULATION AND ADAPTATION; CONTENTS; Preface; Contributors; Chapter 1 Principles of Metabolic Control; Key Concepts; Metabolic Renaissance In Post Genome Era?; Metabolic Engineering; Metabolic Regulation versus Metabolic Control; Complexity of Metabolism and Concept of Biochemical Unity; Basis of Metabolic Control; Pacemaker Enzymes; Identification of a Pacemaker Enzyme; Enzyme Purification; Cautionary Note about Relating In Vitro Kinetic Studies of a Purified Enzyme to Its In Vivo Function and Control; Compartmentation of Metabolism |
Formulation of a Theory of Metabolic ControlMetabolic Control Analysis; Mechanisms of Metabolic Control; Coarse Metabolic Control; Fine Metabolic Control; Concluding Remarks; Chapter 2 Enzymes: The Basis of Catalysis; Introduction; Enzyme Structure; Thermodynamics and Kinetic Theory of Enzyme Function; Thermodynamic Aspects of Kinetic Function: Processes Not Under Enzyme Control; Cellular Equilibria and Enzymes; Reaction Rate Theories; How Enzymes Influence Reaction Rates; How Enzyme-Catalyzed Reactions Occur: Lysozyme as a Model of Transition State Theory |
When Enzymes Need Extra Help: Coenzymes and Their FunctionsCoenzymes That Transfer High Energy Phosphate; Coenzymes That Accept and Donate Electrons; Coenzymes That Activate Substrates; Kinetic Mechanisms of Enzyme Action; Development of Rate Equations: Simple Solution Kinetics; The Haldane Relationship; Multisubstrate Reactions; Cooperative Enzyme Mechanism; Allosteric Enzyme Activation and Inhibition; Enzyme Inhibition; Temperature Effects on Enzyme Function; Estimating Kinetic Parameters from Enzyme Velocity Data (the Influence of Error Structure) |
Chapter 3 Enzymes in the Cell: What's Really Going On?Introduction; Basic Enzyme Mechanism Under In Vivo Conditions; Effect of Enzyme-Substrate Binding; Effect of Reaction Reversibility; Effect of Substrate and Product Binding Combined with Reaction Reversibility; Time Course of the Complete Enzyme Mechanism; Simple Enzyme Systems; Simple Enzyme Pathways under In Vivo Conditions; Thought Experiment: Regulating Flux In Vivo; Mathematical Modeling of the Linear System; Branch Points and Irreversible Enzymes in Pathways; Simple Enzyme Pathways and Crossover Plots |
Basics of Metabolic Control AnalysisMCA Analysis and Metabolic Pathways; Controlling Pathway Flux under In Vivo Conditions: Direct Calculation of Control Coefficients; Controlling Pathway Flux under In Vivo Conditions: Indirect Calculations of Control Coefficients; Relating Flux Control Coefficients to Pathway Regulation; Potential of an Enzyme to Be Regulated; Metabolic Simulation; Supply versus Demand; Feedback Inhibition; Formation of Multienzyme Complexes; Chapter 4 Signal Transduction Pathways and the Control of Cellular Responses to External Stimuli |
Function and Structure of Signaling Pathways |
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Sommario/riassunto |
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Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of |
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metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosi |
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