1.

Record Nr.

UNINA9910812675103321

Autore

Valentine Raymond C

Titolo

Human Longevity

Pubbl/distr/stampa

CRC Press, 2014

ISBN

0-429-16877-2

1-4665-9487-X

Edizione

[1st ed.]

Descrizione fisica

1 online resource (248 p.)

Classificazione

MED008000SCI049000TEC012000

Altri autori (Persone)

ValentineDavid L

Disciplina

612.6/7

Soggetti

Aging - Genetic aspects

Mitochondria

Oxidative stress

Omega-3 fatty acids - Health aspects

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references at the end of each chapters.

Nota di contenuto

Chapter 5: Remarkable Longevity of Queens of Social Insects Likely Involves Dietary Manipulation to Minimize Levels of Polyunsaturates and Decrease Membrane PeroxidationChapter 6: Membrane Peroxidation Hypothesis Helps Explain Longevity in Birds, Rodents, and Whales; Chapter 7: Did Longevity Help Humans Become Super Humans?; Chapter 8: Mitochondrial Diseases and Aging Have Much in Common; Chapter 9: Revised Mitochondrial Hypothesis of Aging Highlights Energy Deficiency Caused by Errors of Replication (Mutations) of mtDNA; Chapter 10: Benefits of Polyunsaturated Mitochondrial Membranes

Chapter 16: Uncoupling Proteins (UCPs) of Mitochondria Purposely Waste Energy to Prevent Membrane DamageChapter 17: Mitochondrial Fission Protects against Oxidative Stress by Minting a Continuous Supply of Cardiolipin and Other Polyunsaturated Phospholipids; Chapter 18: Mitophagy Eliminates Toxic Mitochondria; Chapter 19: Longevity Genes Likely Protect Membranes; Chapter 20: Aging as a Cardiolipin Disease That Can Be Treated; Back Cover

Sommario/riassunto

More than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty



Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman's famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membran