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Record Nr. |
UNINA9910812048003321 |
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Autore |
Yin Guosheng |
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Titolo |
Clinical trial design : Bayesian and frequentist adaptive methods / / Guosheng Yin |
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Pubbl/distr/stampa |
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Hoboken, N.J., : John Wiley & Sons, c2012 |
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ISBN |
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9786613425140 |
9781283425148 |
1283425149 |
9781118183328 |
1118183320 |
9781118183335 |
1118183339 |
9781118183304 |
1118183304 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (366 p.) |
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Collana |
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Wiley series in probability and statistics |
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Disciplina |
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Soggetti |
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Clinical trials - Statistical methods |
Bayesian statistical decision theory |
Mathematical statistics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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Fundamentals of clinical trials -- Frequentist versus Bayesian statistics -- Phase I trial design -- Phase II trial design -- Phase III trial design -- Adaptive randomization -- Late onset toxicity -- Drug combination trials -- Targeted therapy design. |
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Sommario/riassunto |
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A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and |
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