Cancer treatment and the ovary : clinical and laboratory analysis of ovarian toxicity / / edited by Richard A. Anderson, Norah Spears

• Record Nr.: UNINA9910811681603321
• Pubbl/distr/stampa: Amsterdam, [Netherlands] : , : Academic Press, , 2015; ©2015
• ISBN: 0-12-801601-9; 0-12-801591-8
• Descrizione fisica: 1 online resource (164 p.)
• Disciplina: 616.994
• Soggetti: Cancer; Cancer - Treatment - Complications; Ovaries - Cancer - Diagnosis; Ovaries - Cancer - Treatment
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters.
• Nota di contenuto: Front Cover; Cancer Treatment and the Ovary; Copyright Page; Contents; List of Contributors; Foreword; Introduction; I. Clinical; 1 Ovarian Follicle Biology and the Basis for Gonadotoxicity; 1.1 Overview of Ovarian Function; 1.2 Ovarian Development; 1.3 Molecular Mechanisms Controlling Primordial Follicle Activation; 1.4 Local Control of Early Follicle Development; 1.5 Endocrine Control of Later Follicle Development; 1.6 Reproductive Lifespan and the Ovarian Primordial Follicle Reserve; 1.7 Germ Cell Sensitivity to Cell Death; 1.8 Conclusion; References; 2 Relevant Cancer Diagnoses, Commonly Used Chemotherapy Agents and Their Biochemical Mechanisms of Action2.1 Introduction; 2.2 Impact of Radiotherapy on Future Female Fertility; 2.3 Impact of Chemotherapy on Future Female Fertility; 2.4 Mechanisms of Action of the Commonly Used Chemotherapy Drugs; 2.4.1 Alkylating Agents; 2.4.2 Antimetabolites; 2.4.3 Antitumour Antibiotics; 2.4.4 Mitotic Inhibitors; 2.4.5 Platinum Drugs; 2.4.6 Topoisomerase Inhibitors; 2.4.7 High-Dose Chemotherapy; 2.4.8 Targeted Therapies; References; 3 Clinical Assessment of Ovarian Toxicity; 3.1 Introduction; 3.2 The Use of Chemotherapy-Related Amenorrhoea3.3 Biomarkers of the Ovarian Reserve; 3.4 AMH and Determination of Gonadotoxicity; 3.4.1 After Chemotherapy; 3.4.2 Prospective Analyses; 3.4.3 Measurement of AMH; 3.4.4 AMH in Paediatric Oncology; 3.4.5 AMH and Prediction of Reproductive Lifespan and Fertility; 3.5 Conclusion; Acknowledgement; References; 4 The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment; 4.1 Introduction; 4.2 Risk Factors for Premature Ovarian Insufficiency After Chemotherapy; 4.2.1 Age; 4.2.2 Type of Chemotherapy; 4.2.3 Combined Treatment Protocols4.2.3.1 Breast Cancer; 4.2.3.2 Hodgkin Lymphoma; 4.2.3.3 Non-Hodgkin Lymphoma; 4.2.3.4 Leukaemia; 4.2.3.5 Role of Gonadotropin-Releasing Hormone Analogues for the Preservation of Ovarian Function; 4.3 How do Chemotherapeutics Damage The Ovary?; 4.4 The Relevance of BRCA Mutations to Ovarian Damage After Chemotherapy; 4.5 Conclusion; References; II. Laboratory Models; 5 In Vivo Models of Ovarian Toxicity; 5.1 Introduction; 5.2 Rodent Models of Chemotherapy-Induced Follicular Depletion and Ovoprotection; 5.2.1 Chemotherapy-Induced Follicular Depletion; 5.2.2 Cell-Type Specificity of Chemotherapy Toxicity5.2.3 Ovarian Toxicity Lessons from Ovoprotection Studies; 5.2.4 Rodent Studies of Ovarian Chemotherapy Toxicity Compared to Data from Clinical Studies; 5.2.5 Transgenerational Toxicity of Chemotherapy; 5.3 Primate Models of Chemotherapy-Induced Ovarian Toxicity and Ovoprotection; 5.4 Conclusion; References; 6 In Vitro Models of Ovarian Toxicity; 6.1 Introduction; 6.2 Why Use Culture Systems?; 6.3 What Culture Systems are Available?; 6.4 Human and other Primate Model Studies of Ovarian Chemotherapy Toxicity; 6.5 Rodent Model Studies of Ovarian Chemotherapy Toxicity
• Sommario/riassunto: Cancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity provides the reader with a basic understanding on how the ovary is adversely impacted by cancer treatment, an essential foundational knowledge for this rapidly-developing field. The book describes both the clinical and laboratory approaches to discovering the potentially adverse effects of cancer treatment on the ovary, also laying out possible preventative approaches and future directions for the field. Clinicians working in the field of reproductive biology and oncology will find an essential referen